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Bcl XL Human, GST/ 重组人特大B细胞淋巴瘤蛋白, GST
产品编号：PRO-640
产品规格：2μg/10μg/1mg
产品规格：2μg/10μg/1mg
| Synonyms | BclXL, Bcl-X（L）, Bcl-XL. |
| Introduction | Bcl-XL is a transmembrane protein located in the mitochondrial membranes of cells that are long-lived ａnd postmitotic, such as adult brain cells. It plays arole in the signal transduction pathway of the FAS-Ligand. Bcl-XL is an anti-apoptotic protein which is a member of the Bcl-2 family which are able to form heterodimers, ａnd this is an significant event in the regulation of apoptosis. BCL-XL is involved in the survival of cancer cells. Bcl-xL is the leading monitor of apoptosis/active cell suicide. Bcl-xL has cell death repressor activity ａnd therefore acts as a survival protein. |
| Description | Bcl-XL Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing amino acids 1-210. The Bcl-XL is expressed as GST-Tag fusion protein ａnd purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered White lyophilized （freeze-dried） powder. |
| Formulation | The protein contains 10mM Tris-HCL pH-8, 1mM EDTA ａnd 250mM NaCl. |
| Solubility | Suspend BclXL in 100?l of 0.5M Acetic acid, over night at 4°C. Dilute 10 fold into selected buffer system. Bcl-XL has tendency to form intramolecular disulfide bond, 5mM DTT is recommended in assay buffer. When running SDS-PAGE gel, 10mM DTT is recommended. |
| Stability | Lyophilized Bcl-XL although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Bcl-XL should be stored at 4°C between 2-7 days ａnd for future use below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles. |
| Purity | Greater than 95.0% as determined by SDS-PAGE. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
