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HTLV-1 mosaic/重组人T淋巴细胞病毒1嵌合体
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更新日期：2024/10/16 16:00:55
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HTLV-1 mosaic/重组人T淋巴细胞病毒1嵌合体
产品编号：HIV-144
产品规格：100μg/500μg/1mg
Introduction Human T-lymphotropic virus （HTLV） is a human, single-stranded RNA retrovirus that causes T-cell leukemia ａnd T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells ａnd overproduction of Th1 related cytokines （mainly IFN-gamma ａnd TNF-alpha）. Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes ａnd a reduction of Th2 cytokine production （mainly IL-4, IL-5, IL-10 ａnd IL-13）. The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response （these include parasitic infections ａnd production of mucosal ａnd humoral antibodies）. Description The E.Coli derived recombinant mosaic protein contains the gp21 ａnd gp46 immunodominant regions, 374-400 amino acids ａnd 190-207 amino acids, the MW is 42kDa. The protein is fused with GST at N-terminus. Purification Method HTLV-1 Mosaic was purified by proprietary chromatographic technique. Purity HTLV-1 Mosaic protein is >95% pure as determined by 10% PAGE （coomassie staining） ａnd RP-HPLC. Formulation 60mM NaCl, 50mM Tris-HCl pH 8.0, 0.25% Sarkosil, 50% glycerol ａnd 10mM glutathione. Storage HTLV-1 Mosaic protein is shipped at ambient temperature.
Upon arrival, Store at -20°C. Stability Five years frozen. One month in solution at room temperature. Specificity Immunoreactive with all sera of HTLV-I ａnd HTLV-II infected individuals with antibody response to HTLV envelope. Applications HTLV-1 Mosaic can be used as an antigen in ELISA ａnd Western Blots. Excellent reagent for correct detection of HTLV infections, with minimal specificity problems. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
产品规格：100μg/500μg/1mg
| Introduction | Human T-lymphotropic virus （HTLV） is a human, single-stranded RNA retrovirus that causes T-cell leukemia ａnd T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells ａnd overproduction of Th1 related cytokines （mainly IFN-gamma ａnd TNF-alpha）. Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes ａnd a reduction of Th2 cytokine production （mainly IL-4, IL-5, IL-10 ａnd IL-13）. The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response （these include parasitic infections ａnd production of mucosal ａnd humoral antibodies）. |
| Description | The E.Coli derived recombinant mosaic protein contains the gp21 ａnd gp46 immunodominant regions, 374-400 amino acids ａnd 190-207 amino acids, the MW is 42kDa. The protein is fused with GST at N-terminus. |
| Purification Method | HTLV-1 Mosaic was purified by proprietary chromatographic technique. |
| Purity | HTLV-1 Mosaic protein is >95% pure as determined by 10% PAGE （coomassie staining） ａnd RP-HPLC. |
| Formulation | 60mM NaCl, 50mM Tris-HCl pH 8.0, 0.25% Sarkosil, 50% glycerol ａnd 10mM glutathione. |
| Storage | HTLV-1 Mosaic protein is shipped at ambient temperature. Upon arrival, Store at -20°C. |
| Stability | Five years frozen. One month in solution at room temperature. |
| Specificity | Immunoreactive with all sera of HTLV-I ａnd HTLV-II infected individuals with antibody response to HTLV envelope. |
| Applications | HTLV-1 Mosaic can be used as an antigen in ELISA ａnd Western Blots. Excellent reagent for correct detection of HTLV infections, with minimal specificity problems. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
