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HTLV-1 gp46 mosaic/重组人T淋巴细胞病毒gp46嵌合体
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更新日期：2024/10/16 16:00:55
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HTLV-1 gp46 mosaic/重组人T淋巴细胞病毒gp46嵌合体
产品编号：HIV-142
产品规格：100μg/500μg/1mg
Introduction Human T-lymphotropic virus （HTLV） is a human, single-stranded RNA retrovirus that causes T-cell leukemia ａnd T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells ａnd overproduction of Th1 related cytokines （mainly IFN-gamma ａnd TNF-alpha）. Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes ａnd a reduction of Th2 cytokine production （mainly IL-4, IL-5, IL-10 ａnd IL-13）. The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response （these include parasitic infections ａnd production of mucosal ａnd humoral antibodies）. Description The E.Coli derived recombinant mosaic protein contains the gp46 immunodominant regions, 162-214 amino acids ａnd 242-257 amino acids, Mw on SDA-PAGE is 39kDa. Purification Method HTLV-1 gp46 was purified by proprietary chromatographic technique. Purity HTLV-1 gp46 protein is >95% pure as determined by 10% SDS-PAGE （coomassie staining） ａnd RP-HPLC. Formulation 10mM NaPO4 pH 6.0, 0.1% SDS, 1mM DTT, 1mM EDTA. Storage HTLV-1 gp46 protein is shipped at ambient temperature.
Upon arrival, Store at -20°C. Stability Five years frozen. One month in solution at room temperature. Applications HTLV-1 gp46 can be used as an antigen in ELISA ａnd Western Blots. Excellent reagent for correct detection of HTLV infections, with minimal specificity problems. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
产品规格：100μg/500μg/1mg
| Introduction | Human T-lymphotropic virus （HTLV） is a human, single-stranded RNA retrovirus that causes T-cell leukemia ａnd T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells ａnd overproduction of Th1 related cytokines （mainly IFN-gamma ａnd TNF-alpha）. Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes ａnd a reduction of Th2 cytokine production （mainly IL-4, IL-5, IL-10 ａnd IL-13）. The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response （these include parasitic infections ａnd production of mucosal ａnd humoral antibodies）. |
| Description | The E.Coli derived recombinant mosaic protein contains the gp46 immunodominant regions, 162-214 amino acids ａnd 242-257 amino acids, Mw on SDA-PAGE is 39kDa. |
| Purification Method | HTLV-1 gp46 was purified by proprietary chromatographic technique. |
| Purity | HTLV-1 gp46 protein is >95% pure as determined by 10% SDS-PAGE （coomassie staining） ａnd RP-HPLC. |
| Formulation | 10mM NaPO4 pH 6.0, 0.1% SDS, 1mM DTT, 1mM EDTA. |
| Storage | HTLV-1 gp46 protein is shipped at ambient temperature. Upon arrival, Store at -20°C. |
| Stability | Five years frozen. One month in solution at room temperature. |
| Applications | HTLV-1 gp46 can be used as an antigen in ELISA ａnd Western Blots. Excellent reagent for correct detection of HTLV infections, with minimal specificity problems. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
