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HTLV-1 gp21/重组人T淋巴细胞病毒gp21
点击次数：152发布时间：2012/11/7 20:38:59
更新日期：2024/10/16 16:00:55
所 在 地：美洲
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HTLV-1 gp21/重组人T淋巴细胞病毒gp21
产品编号：HIV-141
产品规格：100μg/500μg/1mg
产品规格：100μg/500μg/1mg
| Introdcution | Human T-lymphotropic virus （HTLV） is a human, single-stranded RNA retrovirus that causes T-cell leukemia ａnd T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells ａnd overproduction of Th1 related cytokines （mainly IFN-gamma ａnd TNF-alpha）. Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes ａnd a reduction of Th2 cytokine production （mainly IL-4, IL-5, IL-10 ａnd IL-13）. The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response （these include parasitic infections ａnd production of mucosal ａnd humoral antibodies）. |
| Description | The E.Coli derived recombinant protein contains the gp21 immunodominant region, 351-404 amino acids, the MW is 21kDa. Fused with a GST tag at N-Terminus. |
| Purification Method | HTLV-1 gp21 was purified by proprietary chromatographic technique. |
| Purity | HTLV-1 gp21 is >95% pure as determined by 10% SDS-PAGE （coomassie staining） ａnd RP-HPLC. |
| Formulation | 60mM NaCl, 50mM Tris-HCl, pH-8.0, 0.25% Sarkosil, 50% Glycerol, 10mM Glutathione. |
| Storage | HTLV-1 gp21 protein is shipped at ambient temperature. Upon arrival, Store at -20°C. |
| Stability | Five years frozen. One month in solution at room temperature. |
| Application | HTLV-1 gp21 can be used as an antigen in ELISA ａnd Western Blots. Excellent reagent for correct detection of HTLV infections, with minimal specificity problems. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
