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HTLV-1 Envelope/重组人T淋巴细胞病毒包膜蛋白

点击次数:228发布时间:2012/11/7 20:39:43

HTLV-1 Envelope/重组人T淋巴细胞病毒包膜蛋白

更新日期:2024/10/16 16:00:55

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简单介绍:HTLV-1 Envelope/重组人T淋巴细胞病毒包膜蛋白

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HTLV-1 Envelope/重组人T淋巴细胞病毒包膜蛋白

产品编号:HIV-107
产品规格:100μg/500μg/1mg
 
 
 
Introduction Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).
Description The E.Coli derived recombinant protein contains the C- terminus of gp46 and most of p21E of HTLV-1. This non-fusion, E. coli-derived protein, starts from HIV-1 env. Amino acid 165, and is ending in amino acid 440, Mw 27 kDa.
Purification Method HTLV-1 Envelope was purified by proprietary chromatographic technique.
Purity HTLV-1 Envelope protein is >95% pure as determined by 10% PAGE (coomassie staining) and RP-HPLC.
Formulation 10mM Na-PO4 pH 6.0, 0.1% SDS and 1mM DTT.
Storage HTLV-1 Envelope protein is shipped at ambient temperature. Upon arrival, Store at -20°C.
Stability Five years frozen. One month in solution at room temperature.
Specificity Immunoreactive with all sera of HTLV-I and HTLV-II infected individuals with antibody response to HTLV envelope.
Applications HTLV-1 Envelope can be used as an antigen in ELISA and Western Blots. Excellent reagent for correct detection of HTLV infections, with minimal specificity problems.
Usage ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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