HIV-2 gp-36 （390-702 a.a.）/重组艾滋病毒2 gp36（390-702）

产品编号：HIV-139
产品规格：100μg/500μg/1mg
 

 

 

Introduction	HIV-1 ａnd HIV-2 appear to package their RNA differently. HIV-1 binds to any appropriate RNA whereas HIV-2 preferentially binds to mRNA which creates the Gag protein itself. This means that HIV-1 is better able to mutate. HIV-2 is transmitted in the same ways as HIV-1: Through exposure to bodily fluids such as blood, semen, tears ａnd vaginal fluids. Immunodeficiency develops more slowly with HIV-2. HIV-2 is less infectious in the early stages of the virus than with HIV-1. The infectiousness of HIV-2 increases as the virus progresses. Major differences include reduced pathogenicity of HIV-2 relative to HIV-1, enhanced immune control of HIV-2 infection ａnd often some degree of CD4-independence. Despite considerable sequence ａnd phenotypic differences between HIV-1 ａnd 2 envelopes, structurally they are quite similar. Both membrane-anchored proteins eventually form the 6-helix bundles from the N-terminal ａnd C-terminal regions of the ectodomain, which is common to many viral ａnd cellular fusion proteins ａnd which seems to drive fusion. HIV-1 gp41 helical regions can form more stable 6-helix bundles than HIV-2 gp41 helical regions however HIV-2 fusion occurs at a lower threshold temperature （25°C）, does not require Ca2+ in the medium, is insensitive to treatment of target cells with cytochalasin B, ａnd is not affected by target membrane glycosphingolipid composition.
Description	HIV-2 gp36 34 kDa recombinant- contains the sequence of HIV-2 envelope immunodominant regions gp36, amino acids 390-702. The protein is fused to beta-galactosidase （114 kDa） at N-terminus.
Source	Escherichia Coli.
Physical Appearance	Sterile filtered colorless clear solution.
Formulation	0.01M Na2CO3, 0.01M Na3EDTA, 0.014 M?-mercaptoethanol, 0.02% Sarcosyl.
Purity	Greater than 95.0% as determined by HPLC analysis ａnd SDS-PAGE.
Stability	Protein should be stored at 4°C. Refrigerate Upon arrival. DO NOT FREEZE.
Specificity	Immunoreactive with all sera of HIV-2 infected individuals.
Applications	HIV-2 gp-36 antigen in ELISA ａnd Western blots, excellent antigen for early detection of HIV seroconvertors with minimal specificity problems.
Usage	ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.