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HIV-2 gp32, Biotin/重组艾滋病毒2 gp32，生物素标记
产品编号：HIV-135
产品规格：100μg/500μg/1mg
产品规格：100μg/500μg/1mg
| Introduction | HIV-1 ａnd HIV-2 appear to package their RNA differently. HIV-1 binds to any appropriate RNA whereas HIV-2 preferentially binds to mRNA which creates the Gag protein itself. This means that HIV-1 is better able to mutate. HIV-2 is transmitted in the same ways as HIV-1: Through exposure to bodily fluids such as blood, semen, tears ａnd vaginal fluids. Immunodeficiency develops more slowly with HIV-2. HIV-2 is less infectious in the early stages of the virus than with HIV-1. The infectiousness of HIV-2 increases as the virus progresses. Major differences include reduced pathogenicity of HIV-2 relative to HIV-1, enhanced immune control of HIV-2 infection ａnd often some degree of CD4-independence. Despite considerable sequence ａnd phenotypic differences between HIV-1 ａnd 2 envelopes, structurally they are quite similar. Both membrane-anchored proteins eventually form the 6-helix bundles from the N-terminal ａnd C-terminal regions of the ectodomain, which is common to many viral ａnd cellular fusion proteins ａnd which seems to drive fusion. HIV-1 gp41 helical regions can form more stable 6-helix bundles than HIV-2 gp41 helical regions however HIV-2 fusion occurs at a lower threshold temperature （25°C）, does not require Ca2+ in the medium, is insensitive to treatment of target cells with cytochalasin B, ａnd is not affected by target membrane glycosphingolipid composition. |
| Description | HIV-2 gp32 Biotin Labeled recombinant- contains the full-length sequence of HIV-2 envelope immunodominant regions gp32. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile filtered colorless clear solution. |
| Formulation | 20mM PBS pH-7.8, NaCl 0.5M, DTT 1mM, 8M urea ａnd 0.4M imidasole. |
| Purity | Greater than 95.0% as determined by HPLC analysis ａnd SDS-PAGE. |
| Stability | HIV-2 gp32 Biotin Labeled protein is shipped at ambient temperature. Upon arrival, Store at -20°C Stable for Five years frozen. One month in solution at room temperature. |
| Specificity | Immunoreactive with all sera of HIV-2 infected individuals. |
| Applications | HIV-2 gp32 Biotin Labeled antigen is suitable for ELISA ａnd Western blots, excellent antigen for early detection of HIV seroconvertors with minimal specificity problems. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
