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HIV-1, 2/重组HIV-1 外壳连接HIV-2 gp39
产品编号：HIV-131
产品规格：100μg/500μg/1mg
Introduction HIV-1 ａnd HIV-2 appear to package their RNA differently. HIV-1 binds to any appropriate RNA whereas HIV-2 preferentially binds to mRNA which creates the Gag protein itself. This means that HIV-1 is better able to mutate. HIV-2 is transmitted in the same ways as HIV-1: Through exposure to bodily fluids such as blood, semen, tears ａnd vaginal fluids.
Immunodeficiency develops more slowly with HIV-2.
HIV-2 is less infectious in the early stages of the virus than with HIV-1.
The infectiousness of HIV-2 increases as the virus progresses.Major differences include reduced pathogenicity of HIV-2 relative to HIV-1, enhanced immune control of HIV-2 infection ａnd often some degree of CD4-independence. Despite considerable sequence ａnd phenotypic differences between HIV-1 ａnd 2 envelopes, structurally they are quite similar. Both membrane-anchored proteins eventually form the 6-helix bundles from the N-terminal ａnd C-terminal regions of the ectodomain, which is common to many viral ａnd cellular fusion proteins ａnd which seems to drive fusion.
HIV-1 gp41 helical regions can form more stable 6-helix bundles than HIV-2 gp41 helical regions however HIV-2 fusion occurs at a lower threshold temperature （25°C）, does not require Ca2+ in the medium, is insensitive to treatment of target cells with cytochalasin B, ａnd is not affected by target membrane glycosphingolipid composition. Description HIV-1,2 recombinant- E.Coli derived recombinant 27 kDa protein contains the C- terminus of gp120 ａnd most of gp41. The protein is conjugated to a 23 amino acids synthetic peptide derived from gp39 of HIV-2. Source Escherichia Coli. Physical Appearance Sterile filtered colorless clear solution. Formulation 100 mM Na-PO4, pH 6 & 0.05% SDS. Purity Greater than 95.0% as determined by HPLC analysis ａnd SDS-PAGE. Stability HIV-1,2 protein is shipped at ambient temperature. Upon arrival, Store at -20°C Stable for Five years frozen. One month in solution at room temperature. Specificity Immunoreactive with all sera of HIV-1, HIV type O & HIV-2 infected individuals. Applications HIV-1,2 antigen is suitable for ELISA ａnd Western blots, excellent antigen for early detection of HIV seroconvertors with minimal specificity problems. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
产品规格：100μg/500μg/1mg
| Introduction | HIV-1 ａnd HIV-2 appear to package their RNA differently. HIV-1 binds to any appropriate RNA whereas HIV-2 preferentially binds to mRNA which creates the Gag protein itself. This means that HIV-1 is better able to mutate. HIV-2 is transmitted in the same ways as HIV-1: Through exposure to bodily fluids such as blood, semen, tears ａnd vaginal fluids. Immunodeficiency develops more slowly with HIV-2. HIV-2 is less infectious in the early stages of the virus than with HIV-1. The infectiousness of HIV-2 increases as the virus progresses.Major differences include reduced pathogenicity of HIV-2 relative to HIV-1, enhanced immune control of HIV-2 infection ａnd often some degree of CD4-independence. Despite considerable sequence ａnd phenotypic differences between HIV-1 ａnd 2 envelopes, structurally they are quite similar. Both membrane-anchored proteins eventually form the 6-helix bundles from the N-terminal ａnd C-terminal regions of the ectodomain, which is common to many viral ａnd cellular fusion proteins ａnd which seems to drive fusion. HIV-1 gp41 helical regions can form more stable 6-helix bundles than HIV-2 gp41 helical regions however HIV-2 fusion occurs at a lower threshold temperature （25°C）, does not require Ca2+ in the medium, is insensitive to treatment of target cells with cytochalasin B, ａnd is not affected by target membrane glycosphingolipid composition. |
| Description | HIV-1,2 recombinant- E.Coli derived recombinant 27 kDa protein contains the C- terminus of gp120 ａnd most of gp41. The protein is conjugated to a 23 amino acids synthetic peptide derived from gp39 of HIV-2. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile filtered colorless clear solution. |
| Formulation | 100 mM Na-PO4, pH 6 & 0.05% SDS. |
| Purity | Greater than 95.0% as determined by HPLC analysis ａnd SDS-PAGE. |
| Stability | HIV-1,2 protein is shipped at ambient temperature. Upon arrival, Store at -20°C Stable for Five years frozen. One month in solution at room temperature. |
| Specificity | Immunoreactive with all sera of HIV-1, HIV type O & HIV-2 infected individuals. |
| Applications | HIV-1,2 antigen is suitable for ELISA ａnd Western blots, excellent antigen for early detection of HIV seroconvertors with minimal specificity problems. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
