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HIV-1 gp120 Nef Mosaic/重组HIV1 gp120 nef嵌合体
产品编号：HIV-102
产品规格：100μg/500μg/1mg
产品规格：100μg/500μg/1mg
| Introduction | Human immunodeficiency virus （HIV） is a retrovirusthat can lead to a condition in which the immune systembegins to fail, leading to opportunistic infections. HIV primarily infects vital cells in the humanimmune systemsuch as helper T cells（specifically CD4+ T cells）, macrophagesand dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly, direct viral killing of infected cells; secondly, increased rates of apoptosisin infected cells; ａnd thirdly, killing of infected CD4+ T cells by CD8 cytotoxic lymphocytesthat recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunityis lost, ａnd the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus, part of the family of Retroviridae. Lentiviruses have many common morphologies ａnd biological properties. Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses. Upon entry of the target cell, the viral RNA genomeis converted to double-stranded DNAby a virally encoded reverse transcriptasethat is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integraseso that the genome can be transcribed. Once the virus has infected the cell, two pathways are possible: either the virus becomes latentand the infected cell continues to function, or the virus becomes active ａnd replicates, ａnd a large number of virus particles are liberated that can then infect other cells. |
| Description | HIV-1 gp120 is a non-glycosylated polypeptide chain, containing HIV-1 gp120 N-terminus immunodominant regions, 30-110 amino acids. The protein is fused to a six histidines tag. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile filtered colorless clear solution. |
| Formulation | 10mM Tris-HCl, pH 4.5, 25mM Sodium Phosphate ａnd 8M urea. |
| Purity | Greater than 95.0% as determined by HPLC analysis ａnd SDS-PAGE. |
| Stability | HIV-1 gp120 protein is shipped at ambient temperature. Upon arrival, Store at -20°C. Stable for Five years frozen. One month in solution at room temperature. |
| Specificity | Immunoreactive with all sera of HIV-1 infected individuals. |
| Applications | HIV-1 gp120 antigen is suitable for ELISA ａnd Western blots, excellent antigen for early detection of HIV seroconvertors with minimal specificity problems. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
