HIV-1 nef, Clade B/重组HIV-1 nef, 进化枝B
产品编号：HIV-156
产品规格：2μg/10μg/100μg
产品规格：2μg/10μg/100μg
| Introduction | HIV-1 Nef is a 27kDa protein highly produced after a very short time after virus infection. HIV-1 Nef is an essential factor for efficient viral replication ａnd phatogenesis. HIV-1 Nef facilitates virus replication ａnd improves virions infectivity. HIV-1 Nef exerts pleiotropic effect. HIV-1 Nef down-modulates surface MHC-I molecules, decreases cell surface CD4 antigen by interacting with the Src family kinase LCK thereby inducing LCK-CD4 dissociation ａnd by increasing clathrindependent endocytosis of this antigen to target it to lysosomial degradation. HIV-1 Nef guards the infected cell from apoptosis in order to keep it alive until the next virus generation is ready to strike. HIV-1 Nef protein bypasses host Tcell signaling by inducing a transcriptional program nearly identical to that of anti-CD3 cell activation. |
| Description | The E.coli derived 27 kDa recombinant HIV-1 Nef Clade-B protein is a single non-glycosylated polypeptide chain. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile filtered lyophilized protein. |
| Purity | Greater than 90.0% as determined by HPLC analysis ａnd SDS-PAGE. |
| Solubility | Reconstitute with PBS in apirogenic water or buffer with a minimum ionic force to guarantee the correct folding of Nef protein. |
| Stability | Protein is shipped at ambient temperature. Upon arrival, Store at -20°C. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
