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HIV-1 Envelope, His/重组HIV-1外壳蛋白, His
点击次数：160发布时间：2012/11/9 18:11:18
更新日期：2024/10/16 16:00:55
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HIV-1 Envelope, His/重组HIV-1外壳蛋白, His
产品编号：HIV-152
产品规格：100μg/500μg/1mg
Introduction Human immunodeficiency virus （HIV） is a retrovirusthat can lead to a condition in which the immune systembegins to fail, leading to opportunistic infections. HIV primarily infects vital cells in the humanimmune systemsuch as helper T cells（specifically CD4+ T cells）, macrophagesand dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly, direct viral killing of infected cells; secondly, increased rates of apoptosisin infected cells; ａnd thirdly, killing of infected CD4+ T cells by CD8 cytotoxic lymphocytesthat recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunityis lost, ａnd the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus, part of the family of Retroviridae. Lentiviruses have many common morphologies ａnd biological properties. Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses. Upon entry of the target cell, the viral RNA genomeis converted to double-stranded DNAby a virally encoded reverse transcriptasethat is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integraseso that the genome can be transcribed. Once the virus has infected the cell, two pathways are possible: either the virus becomes latentand the infected cell continues to function, or the virus becomes active ａnd replicates, ａnd a large number of virus particles are liberated that can then infect other cells. Description HIV-1 envelope His Tag Recombinant-is an E.coli-derived 74.18 kDa protein that contains immunodominant regions of gp120 C-terminus ａnd gp41 N-terminus of the HIV1 ａnd having 6X His tag protein on the N-terminus. Source Escherichia Coli. Physical Appearance Sterile filtered colorless clear solution. Formulation 20mM sodium carbonate, pH-9.6 & 0.02% sodium azide. Purity Greater than 95.0% as determined by HPLC analysis ａnd SDS-PAGE. Stability HIV-1 Envelope protein is shipped at ambient temperature. Upon arrival, Store at -20°C Stable for Five years frozen. One month in solution at room temperature. Specificity Immunoreactive with all sera of HIV-1 ａnd HIV-type O infected individuals ａnd with 60-80% of HIV-2 infected individuals. Applications HIV-1 Envelope antigen is suitable for ELISA ａnd Western blots, excellent antigen for early detection of HIV seroconvertors with minimal specificity problems.
产品规格：100μg/500μg/1mg
| Introduction | Human immunodeficiency virus （HIV） is a retrovirusthat can lead to a condition in which the immune systembegins to fail, leading to opportunistic infections. HIV primarily infects vital cells in the humanimmune systemsuch as helper T cells（specifically CD4+ T cells）, macrophagesand dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly, direct viral killing of infected cells; secondly, increased rates of apoptosisin infected cells; ａnd thirdly, killing of infected CD4+ T cells by CD8 cytotoxic lymphocytesthat recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunityis lost, ａnd the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus, part of the family of Retroviridae. Lentiviruses have many common morphologies ａnd biological properties. Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses. Upon entry of the target cell, the viral RNA genomeis converted to double-stranded DNAby a virally encoded reverse transcriptasethat is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integraseso that the genome can be transcribed. Once the virus has infected the cell, two pathways are possible: either the virus becomes latentand the infected cell continues to function, or the virus becomes active ａnd replicates, ａnd a large number of virus particles are liberated that can then infect other cells. |
| Description | HIV-1 envelope His Tag Recombinant-is an E.coli-derived 74.18 kDa protein that contains immunodominant regions of gp120 C-terminus ａnd gp41 N-terminus of the HIV1 ａnd having 6X His tag protein on the N-terminus. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile filtered colorless clear solution. |
| Formulation | 20mM sodium carbonate, pH-9.6 & 0.02% sodium azide. |
| Purity | Greater than 95.0% as determined by HPLC analysis ａnd SDS-PAGE. |
| Stability | HIV-1 Envelope protein is shipped at ambient temperature. Upon arrival, Store at -20°C Stable for Five years frozen. One month in solution at room temperature. |
| Specificity | Immunoreactive with all sera of HIV-1 ａnd HIV-type O infected individuals ａnd with 60-80% of HIV-2 infected individuals. |
| Applications | HIV-1 Envelope antigen is suitable for ELISA ａnd Western blots, excellent antigen for early detection of HIV seroconvertors with minimal specificity problems. |
