产品展示
HIV-1 Envelope/重组HIV-1外壳蛋白
点击次数：184发布时间：2012/11/9 18:12:03
更新日期：2024/10/16 16:00:55
所 在 地：美洲
产品型号：
优质供应
详细内容
慧嘉生物您实验身边的好伙伴
为客户提供“品质的产品”和“*优质的服务”
AssayBiotech CUSABIO Immunoway Santa Abcam Cst jackson Pierce Sigma Amresco Qiagen Cayman abnova millipore invitrogen merk ebioscience prospec
欢迎广大客户咨询，另有大量宣传海报和小礼品赠送。
Q Q：
HIV-1 Envelope/重组HIV-1外壳蛋白
产品编号：HIV-101
产品规格：100μg/500μg/1mg
产品规格：100μg/500μg/1mg
| Introduction | Human immunodeficiency virus （HIV） is a retrovirusthat can lead to a condition in which the immune systembegins to fail, leading to opportunistic infections. HIV primarily infects vital cells in the humanimmune systemsuch as helper T cells（specifically CD4+ T cells）, macrophagesand dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly, direct viral killing of infected cells; secondly, increased rates of apoptosisin infected cells; ａnd thirdly, killing of infected CD4+ T cells by CD8 cytotoxic lymphocytesthat recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunityis lost, ａnd the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus, part of the family of Retroviridae. Lentiviruses have many common morphologies ａnd biological properties. Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses. Upon entry of the target cell, the viral RNA genomeis converted to double-stranded DNAby a virally encoded reverse transcriptasethat is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integraseso that the genome can be transcribed. Once the virus has infected the cell, two pathways are possible: either the virus becomes latentand the infected cell continues to function, or the virus becomes active ａnd replicates, ａnd a large number of virus particles are liberated that can then infect other cells. |
| Description | HIV-1 envelope is an E.coli-derived recombinant protein that composes all of the reported immunogenic determinants found in gp41 ａnd a small portion of gp120. The gene encoding this fusion protein was synthesized using codons optimized for E.coli expression ａnd doesn’t represent a linear HIV-1 envelope sequence. HIV-1 is a non-glycosylated, 233 amino acid polypeptide chain, having a molecular mass of 27275.88 dalton ａnd pI=9.68. HIV-1 envelope protein spans the C-Terminus of gp120 ａnd most of gp41. Superior diagnostic reagent for HIV-1 ａnd HIV type-O detection. Detects all HIV-1 ａnd HIV-type O infected individuals responding to envelope proteins. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile filtered colorless clear solution. |
| Formulation | The HIV-1 contains 0.5X PBS & 6M urea. |
| Purity | Greater than 95.0% as determined by HPLC analysis ａnd SDS-PAGE. |
| Stability | HIV-1 Envelope protein is shipped at ambient temperature. Upon arrival, Store at -20°C Stable for Five years frozen. One month in solution at room temperature. |
| Specificity | Immunoreactive with all sera of HIV-1 ａnd HIV-type O infected individuals ａnd with 60-80% of HIV-2 infected individuals. |
| Applications | HIV-1 Envelope antigen is suitable for ELISA ａnd Western blots, excellent antigen for early detection of HIV seroconvertors with minimal specificity problems. |
