HCV NS3/重组丙型肝炎病毒NS3（1450-1643 a.a.）
产品编号：HCV-255
产品规格：100μg/500μg/1mg
Introduction HCV is a small 50nm, enveloped, single-stranded, positive sense RNAvirus in the family Flaviviridae.
HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host＇s immune response. Hepatitis C virus is classified into six genotypes（1-6） with several subtypes within each genotype. The preponderance ａnd distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy ａnd the required duration of such therapy. Genotypes 1 ａnd 4 are less responsive to interferon-based treatment than are the other genotypes （2, 3, 5 ａnd 6）. Description The E.coli derived 22kDa recombinant protein contains the HCV NS3 genotype 1b immunodominant regions, amino acids 1450-1643. The protein is fused with b-galactosidase （114 kDa） at N-terminus, pI 5.43. Purification Method HCV NS3 protein was purified by proprietary chromatographic technique. Purity HCV NS3 protein is >95% pure as determined by 10% PAGE （coomassie staining）. Formulation 20mM Tris-Hcl pH-8, 8M urea &10mM B-ME. Storage HCV NS3 protein is shipped at ambient temperature.
Upon arrival, Store at -20°C. Stability Five years frozen. One month in solution at room temperature. Specificity Immunoreactive with sera of HCV-infected individuals. Applications HCV NS3 antigen is suitable for ELISA ａnd Western blots, excellent antigen for detection of HCV with minimal specificity problems. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
产品规格：100μg/500μg/1mg
| Introduction | HCV is a small 50nm, enveloped, single-stranded, positive sense RNAvirus in the family Flaviviridae. HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host＇s immune response. Hepatitis C virus is classified into six genotypes（1-6） with several subtypes within each genotype. The preponderance ａnd distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy ａnd the required duration of such therapy. Genotypes 1 ａnd 4 are less responsive to interferon-based treatment than are the other genotypes （2, 3, 5 ａnd 6）. |
| Description | The E.coli derived 22kDa recombinant protein contains the HCV NS3 genotype 1b immunodominant regions, amino acids 1450-1643. The protein is fused with b-galactosidase （114 kDa） at N-terminus, pI 5.43. |
| Purification Method | HCV NS3 protein was purified by proprietary chromatographic technique. |
| Purity | HCV NS3 protein is >95% pure as determined by 10% PAGE （coomassie staining）. |
| Formulation | 20mM Tris-Hcl pH-8, 8M urea &10mM B-ME. |
| Storage | HCV NS3 protein is shipped at ambient temperature. Upon arrival, Store at -20°C. |
| Stability | Five years frozen. One month in solution at room temperature. |
| Specificity | Immunoreactive with sera of HCV-infected individuals. |
| Applications | HCV NS3 antigen is suitable for ELISA ａnd Western blots, excellent antigen for detection of HCV with minimal specificity problems. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
