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Bcl-6 Oncoprotein蛋白抗体
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产品摘要：Bcl-6 protein is mainly expressed in normal germinal center B cells and related lymphomas.
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详细内容
Bcl-6 Oncoprotein蛋白抗体
Clone LN22
7 mL BOND ready-to-use PA0204 P (HIER)
Antigen Background
Bcl-6 is a proto-oncogene that encodes a Kruppel-type zinc-finger protein of
95 kD ａnd shares homology with other transcription factors. Bcl-6 protein is
mainly expressed in normal germinal center B cells ａnd related lymphomas.
It has been shown that the Bcl-6 proto-oncogene is involved in chromosome
rearrangements at 3q27 in non-Hodgkin＇s lymphomas ａnd Bcl-6 rearrangements have also been detected in 33 to 45 percent of diffuse large B cell
lymphomas. Immunohistochemistry has been reported to show the Bcl-6
gene product to be detectable in follicular lymphomas, diffuse large B cell
lymphomas, Burkitt＇s lymphomas ａnd in nodular, lymphocyte predominant
Hodgkin＇s disease.
Also available as a liquid concentrate, refer to page 99
Human diffuse large B cell lymphoma: immunohistochemical staining for Bcl-6 using PA0204.
Note nuclear staining of neoplastic cells. Paraffin section.
Clone LN22
7 mL BOND ready-to-use PA0204 P (HIER)
Antigen Background
Bcl-6 is a proto-oncogene that encodes a Kruppel-type zinc-finger protein of
95 kD ａnd shares homology with other transcription factors. Bcl-6 protein is
mainly expressed in normal germinal center B cells ａnd related lymphomas.
It has been shown that the Bcl-6 proto-oncogene is involved in chromosome
rearrangements at 3q27 in non-Hodgkin＇s lymphomas ａnd Bcl-6 rearrangements have also been detected in 33 to 45 percent of diffuse large B cell
lymphomas. Immunohistochemistry has been reported to show the Bcl-6
gene product to be detectable in follicular lymphomas, diffuse large B cell
lymphomas, Burkitt＇s lymphomas ａnd in nodular, lymphocyte predominant
Hodgkin＇s disease.
Also available as a liquid concentrate, refer to page 99
Human diffuse large B cell lymphoma: immunohistochemical staining for Bcl-6 using PA0204.
Note nuclear staining of neoplastic cells. Paraffin section.
热门标签：Bcl-6 蛋白抗体 Bcl-6 Oncoprotein
