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Beta-Catenin
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产品摘要：Beta-catenin is a component of the adherens junction, a multiprotein complex which supports Ca2+ -dependent cell to cell contact which in itself is critical for adhesion
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详细内容
Beta-Catenin
Clone 17C2
7 mL BOND ready-to-use PA0083 P (HIER)
Antigen Background
The catenins, (alpha, beta ａnd gamma) are cytoplasmic proteins which bind
to the highly conserved tail of the E-cadherin molecule. Beta-catenin is a
component of the adherens junction, a multiprotein complex which supports
Ca2+ -dependent cell to cell contact which in itself is critical for adhesion,
signal transmission ａnd for anchoring the actin cytoskeleton. Beta-catenin’s
role is as a transcription effector of the wnt-signalling pathway. Immunohistochemistry is the best way to demonstrate nuclear expression of betacatenin ａnd wnt-pathway activation. This aberrant expression is observed in
human tumorigenesis ａnd especially in colorectal cancer.
Also available as a liquid concentrate, refer to page 100
Colon polyp: immunohistochemical staining with BOND ready-to-use Beta-Catenin (17C2)
using BOND Polymer Refine Detection.
Clone 17C2
7 mL BOND ready-to-use PA0083 P (HIER)
Antigen Background
The catenins, (alpha, beta ａnd gamma) are cytoplasmic proteins which bind
to the highly conserved tail of the E-cadherin molecule. Beta-catenin is a
component of the adherens junction, a multiprotein complex which supports
Ca2+ -dependent cell to cell contact which in itself is critical for adhesion,
signal transmission ａnd for anchoring the actin cytoskeleton. Beta-catenin’s
role is as a transcription effector of the wnt-signalling pathway. Immunohistochemistry is the best way to demonstrate nuclear expression of betacatenin ａnd wnt-pathway activation. This aberrant expression is observed in
human tumorigenesis ａnd especially in colorectal cancer.
Also available as a liquid concentrate, refer to page 100
Colon polyp: immunohistochemical staining with BOND ready-to-use Beta-Catenin (17C2)
using BOND Polymer Refine Detection.
