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phospho-c-Jun(Thr249)磷酸化原癌基因c-Jun抗体
点击次数：270发布时间：2012/12/3 20:31:55
更新日期：2024/9/5 14:42:48
所 在 地：中国大陆
产品型号：BY-5462R
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货号：BY-5462R
英文名称：Anti-phospho-c-Jun（Thr249）
中文名称：磷酸化原癌基因c-Jun抗体
其他名称：Activator Protein 1; AP 1; AP1; Enhancer Binding Protein AP1; Jun Activation Domain Binding Protein; JUN; Jun oncogene; JUN protein; JUNC; p39; Proto oncogene cJun; Transcription Factor AP1; V jun avian sarcoma virus 17 oncogene homolog; vJun Avian Sarcoma Virus 17 Oncogene Homolog.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 36kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, hrs, cow, dog, chk, pig
产品介绍：The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, ａnd it encodes a protein which is highly homologous to the viral protein. cJun （previously known as the Fos binding protein p39） ａnd c Fos form a complex in the nucleus. AP 1 （activating protein 1） is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression ａnd function of cell cycle regulators such as Cyclin D1, p53, p21 （cip1/waf1）, p19 （ARF） ａnd p16. Fos ａnd Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations ａnd deletions in human malignancies.C-jun（Oncoprotein C-jun：active protein 1）基因与鸟类肉瘤病毒17的转化基因具有同源性，是早期应答基因家族成员。主要用于各种恶性肿瘤的研究。 C-jun又称：应激活化蛋白激酶。
