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CD36/PAS-4CD36抗体
点击次数:245发布时间:2012/12/3 20:40:30
更新日期:2024/9/5 14:42:48
所 在 地:中国大陆
产品型号:BY-1100R
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详细内容
货号:BY-1100R
英文名称:Anti-CD36/PAS-4
中文名称:CD36抗体
其他名称:Platelet glycoprotein IV; GPIV; lycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; Platelet collagen receptor; Fatty acid translocase; FAT; Thrombospondin receptor.
抗体来源:Rabbit
克隆类型:polyclonal
蛋白分子量:predicted molecular weight: 52kDa
纯化方法:affinity purified by Protein A
交叉反应:mo, rat, dog, pig, bov, hrs
产品介绍:Endothelial Markers The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Three alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.Function : Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects.Subunit : Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity.Subcellular Location : Membrane; Multi-pass membrane protein.Tissue Specificity : Predominant in heart, intestine, spleen, fat, skeletal muscle, lower in testes.Similarity : Belongs to the CD36 family.CD36属一种多功能细胞膜受体,CD36参与长链脂肪酸的吸附和调节细胞凋亡残物的清理和巨噬细胞的吞噬作用, 属于一种抗蛋白酶血小板膜表面糖蛋白。 CD36 广泛在单核细胞、巨噬细胞、内皮层细胞、血小板、红细胞前板、脂肪细胞、肌肉细胞以及乳腺内皮层细胞中有不同的表达。CD36抗原是血小板反应素的配体,两者结合后产生抑制肿瘤血管生成的效应。产品图片Antigen: bs-1100P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bs-0295G-HRP) at 1: 5000; TMB(C-0024) staining; Read the data in MicroplateReader by 450nm.