产品展示
CYP19/CYP19A1细胞色素P450 19抗体
点击次数：304发布时间：2012/12/3 20:43:24
更新日期：2024/9/5 14:42:48
所 在 地：中国大陆
产品型号：BY-1292R
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货号：BY-1292R
英文名称：Anti-CYP19/CYP19A1
中文名称：细胞色素P450 19抗体
其他名称：ARO 1; ARO; ARO1; CPV; CYAR; CYP19; CYP19A1; CYPXIX; Cytochrome P450 19A1; Cytochrome P450 family 19 subfamily A polypeptide 1; Estrogen synthetase; MGC104309; P 450AROM; P450AROM.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 55kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, dog, pig
产品介绍：This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism ａnd synthesis of cholesterol, steroids ａnd other lipids. This protein localizes to the endoplasmic reticulum ａnd catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone ａnd in growth or differentiation. The gene expresses two transcript variants. Belongs to the cytochrome P450 family.Subcellular Location : Membrane; Peripheral membrane protein.Tissue Specificity : Brain, placenta ａnd gonads.Similarity : Belongs to the cytochrome P450 family.芳香化酶基因（CYP19）编码的芳香化酶是催化雄激素向雌激素转化的关键酶,CYP19的变异可使芳香化酶活性改变,导致雌激素水平的改变,从而使乳腺癌易感性发生改变,也可能影响到乳腺癌内分泌治疗的敏感性。 目前关于CYP19基因多态性与乳腺癌之间的关系仍存在争论,尚需深入研究以明确芳香化酶的基因多态性在乳腺癌发生中的作用,以及该基因多态性对芳香化酶功能的影响。
