本公司经销CD328/Siglec 7，唾液酸结合性免疫球蛋白样凝集素7抗体，克隆类型为polyclonal，宿主来源是Rabbit，CD328/Siglec 7唾液酸结合性免疫球蛋白样凝集素7抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2466R
英文名称：Anti-CD328/Siglec 7
中文名称：唾液酸结合性免疫球蛋白样凝集素7抗体
其他名称：Sialic acid-binding Ig-like lectin 7; Adhesion inhibitory receptor molecule 1; Adhesion inhibitory receptor molecule 1, siglec-7; AIRM 1; AIRM1; CD328; CD328 antigen; CDw328; D siglec; D siglec precursor; P75; p75/AIRM1; QA79; QA79 membrane protein; Sialic acid binding Ig like lectin 7 precursor; Sialic acid binding immunoglobulin like lectin 7; SIGLEC7.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 51kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：Siglec 7 is a member of the Siglec （sialic acid-binding immunoglobulin like lectin） subgroup of the immunoglobulin superfamily. Siglec 7 is able to mediate high levels of sialic acid-dependent binding to human erythrocytes ａnd soluble sialoglycoconjugates. Addition of anti-Siglec 7 to haematopoietic cell cultures leads to reduced cell growth ａnd prevents the development of dendritic cells. Predominantly expressed by resting ａnd activated natural killer cells ａnd at lower levels by granulocytes ａnd monocytes. High expression can be found in tissues like the placenta, liver, lung, spleen, ａnd peripheral blood leukocytes.Subunit : Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- ａnd alpha-2,6-linked sialic acid. Also binds disialogangliosides （disialogalactosyl globoside, disialyl lactotetraosylceramide ａnd disialyl GalNAc lactotetraoslylceramide）. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase（s） via their SH2 domain（s） that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage ａnd proliferation of leukemic myeloid cells （in vitro）.Subcellular Location : Membrane.Tissue Specificity : Predominantly expressed by resting ａnd activated natural killer cells ａnd at lower levels by granulocytes ａnd monocytes. High expression found in placenta, liver, lung, spleen, ａnd peripheral blood leukocytes.Post-translational modifications : Tyrosine phosphorylated.Similarity : Belongs to the immunoglobulin superfamily. SIGLEC （sialic acid binding Ig-like lectin） family.Contains 2 Ig-like C2-type （immunoglobulin-like） domains.Contains 1 Ig-like V-type （immunoglobulin-like） domain.树突状细胞标志物 神经元细胞标志物