本公司经销Corin，心脏特异性丝氨酸蛋白酶抗体，克隆类型为polyclonal，宿主来源是Rabbit，Corin心脏特异性丝氨酸蛋白酶抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-7685R
英文名称：Anti-Corin
中文名称：心脏特异性丝氨酸蛋白酶抗体
其他名称：ATC 2; ATC2; Atrial natriuteric peptide converting enzyme; Corin serine peptidase; CRN; Heart specific serine proteinase; Heart specific serine proteinase ATC2; Lrp 4 ; Lrp4; Pro ANP convertase; Pro ANP converting enzyme; TMPRSS 10; Transmembrane protease serine 10.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 115kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, pig, dog
产品介绍：Corin was first described as a trypsin-like serine proteinase in the heart which processed pro-atrial natriuretic peptide into the active form ANP. Corin cleaves pro-ANP at Arg98/Ser-99, ａnd blocking Corin message inhibits pro-ANP processing. Null mutant mice lacking Corin develop hypertension, ａnd a series of missense mutations have been identified in humans with high blood pressure ａnd hypertension. Corin is a member of the type-II transmembrane serine proteinases, such as Hepsin, Epitheliasin, Matriptase ａnd enteropeptidase. The Corin domain structure includes a cytoplasmic domain, a transmembrane domain, a spacer region, a frizzled-like domain, 5 LDL Receptor-like domains, another frizzled-like domain, 3 more LDLR-like repeats, a SRCR （Scavenger Receptor-Cysteine Rich） domain （also called macrophage scavenger-like domain）, ａnd finally the trypsin-like serine proteinase domain. The complex domain structure puts Corin into the “mosaic” TMPRSS family, so named because of the wide variety of domains.Subcellular Location : Cell membrane; Single-pass type II membrane protein. Isoform 2: Cell membrane; Single-pass type II membrane protein. Note=Less efficiently targeted to the cell membrane compared to isoform 1. Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment: Secreted. Note=Soluble form produced following cleavage by ADAM10. Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage. Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage.Tissue Specificity : Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus.Similarity : Belongs to the peptidase S1 family.Contains 2 FZ （frizzled） domains.Contains 7 LDL-receptor class A domains.Contains 1 peptidase S1 domain.Contains 1 SRCR domain.