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CDKN2A/P16抑癌基因p16抗体
点击次数：315发布时间：2012/12/3 20:49:57
更新日期：2024/9/5 14:42:48
所 在 地：中国大陆
产品型号：BY-0740R
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货号：BY-0740R
英文名称：Anti-CDKN2A/P16
中文名称：抑癌基因p16抗体
其他名称：cyclin-dependent kinase inhibitor 2A;CDK4I; p16-INK4; p16-INK4a; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A, isoform 1; Cyclin dependent kinase inhibitor 2A （p16, inhibits CDK4）; cell cycle inhibitor; cyclin-dependent kinase inhibitor 2a p16Ink4a; cell cycle regulator; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 2; Cdkn2a; Arf; INK4A; MTS1; p16; p16Cdkn2a; p19ARF.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 17kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig
产品介绍：P16（CDKN2A）A family of cell cycle regulatory proteins designated “mitotic inhibitors” play a major role in regulating the orderly progression through the cell cycle. These protein bind to cyclin dependent kinases ａnd inhibit the catalytic acitivity of the Cdk-cyclin complexes. Member of the mitotic inhibitor family include p21, p27, p57, p16, p15, p18, p19 ａnd p19ARF is an alternative splice product of the murine p16 gene ａnd is known to induce cell cycle arrest. The humanhomlog p14ARF induces cell cycle arrest in both G1 ａnd G2/M in a p53-dependent fashion.细胞周期失控是癌变的重要原因。p16是近年来发现的个直接参与细胞周期调控的抑癌基因，其表达产物为p16蛋白.p16基因是一种重要的抑癌基因，在正常细胞中起负反馈作用，当p16基因突变或丢失时，细胞增殖失去控制使细胞无限制地增殖。p16主要功能是通过抑制CDK4而阻止细胞由G1期进入S期，使细胞增殖受到限制。用于各种恶性肿瘤如肺癌、恶黑、乳腺癌的研究。目前的研究细胞周期依赖激酶抑制p16INK4a蛋白在宫颈上皮内病变（CIN）中作为一个新标记物.p16INK4a的过表达与HPV E7区（病毒早期蛋白即病毒致癌基因编码区）活性有密切相关性。p16/CDKN2基因是新近发现的肿瘤抑制基因，已有研究表明该基因在许多肿瘤出现缺失、突变或重排现象.
