本公司经销COPS2/TRIP15，甲状腺受体相互作用蛋白15抗体，克隆类型为polyclonal，宿主来源是Rabbit，COPS2/TRIP15甲状腺受体相互作用蛋白15抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-9125R
英文名称：Anti-COPS2/TRIP15
中文名称：甲状腺受体相互作用蛋白15抗体
其他名称：ALIEN; Alien homolog; COP 9; COP9; COP9 constitutive photomorphogenic homolog subunit 2; COP9 signalosome complex subunit 2; COPS 2; Cops2; CSN2; CSN2_HUMAN; JAB1 containing signalosome subunit 2; JAB1-containing signalosome subunit 2; SGN 2; SGN2; Signalosome subunit 2; Thyroid Hormone Receptor Interactor15; Thyroid Hormone Receptor Interactor 15; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP 15; TRIP-15.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 51kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, dog, pig
产品介绍：Essential component of the COP9 signalosome complex （CSN）, a complex involved in various cellular ａnd developmental processes. The CSN complex is an essential regulator of the ubiquitin （Ubl） conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 ａnd IRF8/ICSBP, possibly via its association with CK2 ａnd PKD kinases. CSN-dependent phosphorylation of TP53 ａnd JUN promotes ａnd protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.Function : Essential component of the COP9 signalosome complex （CSN）, a complex involved in various cellular ａnd developmental processes. The CSN complex is an essential regulator of the ubiquitin （Ubl） conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 ａnd IRF8/ICSBP, possibly via its association with CK2 ａnd PKD kinases. CSN-dependent phosphorylation of TP53 ａnd JUN promotes ａnd protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.Subunit : Interacts with NIF3L1 （By similarity）. Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 （COPS7A or COPS7B） ａnd COPS8. In the complex, it probably interacts directly with COPS1, COPS4, COPS5 COPS6 ａnd COPS7 （COPS7A or COPS7B）. Interacts with CUL1 ａnd CUL2. Specifically interacts with the ligand binding domain of the thyroid receptor （TR）. Does not require the presence of thyroid hormone for its interaction. Interacts with IRF8/ICSBP1 ａnd with nuclear receptors NR2F1 ａnd NR0B1.Subcellular Location : Cytoplasm. Nucleus.Post-translational modifications : Phosphorylated by CK2 ａnd PKD kinases.Similarity : Belongs to the CSN2 family.Contains 1 PCI domain.