产品展示
COPS6信号转导蛋白亚基6抗体
点击次数：180发布时间：2012/12/3 20:50:33
更新日期：2024/9/5 14:42:48
所 在 地：中国大陆
产品型号：BY-9120R
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详细内容
货号：BY-9120R
英文名称：Anti-COPS6
中文名称：信号转导蛋白亚基6抗体
其他名称：JAB1 containing signalosome subunit 6;COP9 subunit 6 （MOV34 homolog, 34 kD）;MOV34 homolog, 34 kD;COP9 （constitutive photomorphogenic）, subunit 6; COP9 complex S6;COP9 signalosome complex subunit 6;COP9 signalosome subunit 6;cops6;CSN6;CSN6_HUMAN;hVIP;JAB1-containing signalosome subunit 6;MOV34 homolog;MOV34-34KD;Sgn3;SGN6;Signalosome subunit 6;VIP/MOV34;Vpr interacting protein;Vpr-interacting protein.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 36kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, dog, cow
产品介绍：Component of the COP9 signalosome complex （CSN）, a complex involved in various cellular ａnd developmental processes. The CSN complex is an essential regulator of the ubiquitin （Ubl） conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 ａnd IRF8, possibly via its association with CK2 ａnd PKD kinases. CSN-dependent phosphorylation of TP53 ａnd JUN promotes ａnd protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity.Subcellular Location : Nucleus. Cytoplasm. The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region.Tissue Specificity : Widely expressed.
