产品展示
COPS4信号转导蛋白亚基4抗体
点击次数：303发布时间：2012/12/3 20:50:50
更新日期：2024/9/5 14:42:48
所 在 地：中国大陆
产品型号：BY-9123R
优质供应
详细内容
货号：BY-9123R
英文名称：Anti-COPS4
中文名称：信号转导蛋白亚基4抗体
其他名称：CH4;COP9 （constitutive photomorphogenic） homolog subunit 4;COP9 complex homolog subunit 4;COP9 complex S4;COP9 constitutive photomorphogenic homolog subunit 4;COP9 signalosome complex subunit 4;COP9 signalosome subunit 4;COPS4;CSN complex subunit 4;CSN4;CSN4 SCHPO;CSN4_HUMAN;DCH4;JAB1 containing signalosome subunit 4;JAB1-containing signalosome subunit 4;MGC94896;SGN4;Signalosome subunit 4.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 49kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Component of the COP9 signalosome complex （CSN）, a complex involved in various cellular ａnd developmental processes. The CSN complex is an essential regulator of the ubiquitin （Ubl） conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 ａnd IRF8/ICSBP, possibly via its association with CK2 ａnd PKD kinases. CSN-dependent phosphorylation of TP53 ａnd JUN promotes ａnd protects degradation by the Ubl system, respectively.Subcellular Location : Cytoplasm. Nucleus.
