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CD226/DNAM-1CD226抗体
点击次数:414发布时间:2012/12/3 20:56:19
更新日期:2024/9/5 14:42:48
所 在 地:中国大陆
产品型号:BY-2569R
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货号:BY-2569R
英文名称:Anti-CD226/DNAM-1
中文名称:CD226抗体
其他名称:DNAX accessory molecule 1; adhesion glycoprotein; CD226 antigen; DNAM1; platelet and T cell activation antigen 1; PTA1; TLiSA1.
抗体来源:Rabbit
克隆类型:polyclonal
蛋白分子量:predicted molecular weight: 35kDa
纯化方法:affinity purified by Protein A
交叉反应:hu, mo, rat, pig, hrs, cow, Rb
产品介绍:CD226 is a receptor expressed by peripheral blood T lymphocytes that is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T lymphocytes. CD226 is broadly expressed on T cells, NK cells, platelets, monocytes and a subset of B cells. CD226 is also expressed by a subset of CD3 positive thymocytes.Subunit : Interacts with PVR and PVRL2.Subcellular Location : Membrane; Single-pass type I membrane protein.Tissue Specificity : Expressed by peripheral blood T-lymphocytes.Similarity : Contains 2 Ig-like C2-type (immunoglobulin-like) domains.CD226分子是一种广泛表达于多种免疫细胞膜表面的Ⅰ型跨膜糖蛋白,CD226广泛表达于T细胞、NK细胞、NK T细胞、活化的血管内皮细胞、巨核/血小板谱系、单核细胞、胸腺细胞、某些B细胞亚群、部分造血干细胞和肥大细胞等免疫细胞表面,在免疫系统以外则分布于海马和小脑皮质的神经突触部位。CD226与其配体的相互作用参与CTL和NK细胞的活化、分化和细胞毒作用,调节CD4+ T细胞的增殖和分化,介导内皮细胞与其他细胞的黏附,促进血小板的活化与聚集,参与造血调控,介导肥大细胞的脱颗粒作用,参与NK T细胞和胸腺细胞的抗凋亡作用、树突状细胞的成熟、免疫突触和神经突触的形成,并与肿瘤、自身免疫性疾病、移植排斥及病毒感染等疾病密切相关。