本公司经销CD74/MHC II，CD74抗体，克隆类型为polyclonal，宿主来源是Rabbit，CD74/MHC IICD74抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2518R
英文名称：Anti-CD74/MHC II
中文名称：CD74抗体
其他名称：MHC-II; invariant polypeptide of major histocompatibility complex, class II antigen-associated; CD 74; CD74 antigen; CD74 molecule; CLIP; DHLAG; Gamma chain of class II antigens; HLA class II histocompatibility antigen gamma chain; HLA DR antigens associated invariant chain; HLA DR gamma; HLA-DR-gamma; HLADG; HLADR antigens associated invariant chain; Ia antigen associated invariant chain; Ia associated invariant chain; Ia gamma; Ii; la-gamma; Major histocompatibility complex class II invariant chain; MHC HLA DR gamma chain; MHC HLA-DR gamma chain; p33; p35; Protein 41.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 34kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：CD74, also known as the MHC class II associated invariant chain （Ii）, is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers ａnd prevents their premature association with endogenous polypeptides. CD74 is produced in molar excess over MHC class II ａnd some of this is expressed by an unknown pathway on the cell surface independent of, or in association with, MHC class II molecules. The half life of CD74 on the cell surface is only 3 to 4 min after which it is internalized. It has been proposed that cell surface CD74 binds MHC class II molecules which have lost their antigenic peptide leading to internalization ａnd reloading with antigenic peptide. The transport route of class II alpha/beta/Ii complexes is regulated selectively by two forms of CD74 （p33 ａnd p35） which are generated by the use of alternative translation initiation sites. CD74 is expressed primarily by antigen presenting cells such as B lymphocytes （from before the pre-B cell stage to before the plasma cell stage）, macrophages ａnd monocytes together, with many epithelial cells. CD74 may exist in different isoforms ranging in size from 33 to 41 kDa, depending on genetic splicing.CD74表达于所有B细胞和某些T细胞亚类（MHC II阳性），具有几种异构体形式（33，35和41kDa），是HLA-DR的恒定链。该抗体主要用于标记生发中心及外套B细胞（80%）和R-S细胞（70%）以及少数T细胞（20%），常与其它B细胞标记如CD20或CD45RA联合检测，用于B细胞淋巴瘤的辅助诊断。