本公司经销CD163/M130，CD163抗体，克隆类型为polyclonal，宿主来源是Rabbit，CD163/M130CD163抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2527R
英文名称：Anti-CD163/M130
中文名称：CD163抗体
其他名称：Scavenger receptor cysteine-rich type 1 protein M130; CD 163; CD163 antigen; CD163 molecule; Hemoglobin Scavenger Receptor; M130; M130 antigen precursor; Macrophage associated antigen; MM130
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 130kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, cow, hrs, dog
产品介绍：CD163 is a 130 kDa membrane glycoprotein. It is a member of the scavenger receptor cysteine-rich superfamily ａnd is a receptor for the hemoglobin-haptoglobin complex. CD163 is expressed exclusively on the cell surface of human monocytes ａnd macrophages that evolve predominantly in the late phase of inflammation. CD163 is present on all CD14 positive monocytes, most CD64 positive monocytes, ａnd shows higher expression on CD16 positive monocytes. CD163 is upregulated on mononuclear phagocytes by IL-10, IL-6 ａnd dexamethasone. Lipopolysaccharide （LPS） ａnd phorbol myristate acetate （PMA） both induce shedding of CD163 from the cell surface into plasma or cell supernatant.Function : Acute phase-regulated receptor involved in clearance ａnd endocytosis of hemoglobin/haptoglobin complexes by macrophages ａnd may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake ａnd recycling of iron, via endocytosis of hemoglobin/haptoglobin ａnd subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent ａnd pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin ａnd multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin ａnd dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production ａnd secretion of IL6 ａnd CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis ａnd the more pronounced surface expression when expressed in cells.Subcellular Location : Secreted ａnd Cell membrane. Isoform 1 ａnd isoform 2 show a lower surface expression when expressed in cells.Tissue Specificity : Expressed in monocytes ａnd mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages ａnd meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver ａnd the spleen. Isoform 3 is the predominant isoform detected in the blood.Post-translational modifications : A soluble form （sCD163） is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester ａnd Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C ａnd tyrosine kinases ａnd can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, ａnd thus probably induced by membrane-bound metalloproteinases ADAMs.Phosphorylated.Similarity : Contains 9 SRCR domains.CD163是SRCR超家族成员，又称为血红蛋白清道夫受体（hemoglobin scavenger receptor, HbSR）、M130或p155。CD163的表达水平受很多因素调节，糖皮质激素及抗炎介质如IL-10以及IL-6能上调CD163, 而促炎介质如脂多糖（lipopolysaccharide, LPS）、γ-干扰素（interferon-γ， IFN-γ）以及TNF-α则抑制CD163表达。 CD163是一种I型膜蛋白，又称为M130抗原、Ber-Mac3、Ki-M8或SM4。CD163限制性表达于单核/巨噬细胞系，所有循环系统的单核细胞和大多数组织（除外淋巴滤泡套区和生发中心）的巨噬细胞均阳性表达，主要用于单核/巨噬细胞的检测。