本公司经销CMKLR1，趋化样因子受体1抗体，克隆类型为polyclonal，宿主来源是Rabbit，CMKLR1趋化样因子受体1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2530R
英文名称：Anti-CMKLR1
中文名称：趋化样因子受体1抗体
其他名称：Chemokine receptor-like 1; CHEMR23; ChemR23; DEZ; Chemokine like receptor 1; G protein coupled receptor ChemR23; G protein coupled receptor DEZ ; Orphan G protein coupled recepto.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 41kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, Gpig
产品介绍：Chemokine-Like Receptor 1 （CMKLR1） is a serpentine transmembrane G-protein linked receptor. It is an orphan chemoattractant receptor, also known as ChemR23 or DEZ. CMKLR1 is expressed on the surface of monocyte-derived immature dendritic cells ａnd peripheral plamacytoid dendritic （pDC） cells; but not on myeloid dendritic （mDC） cells, monocytes ａnd lymphocytes. The expression of CMKLR1 on pDC is down-regulated after activation. Chemerin （TIG2） is a natural ligand of CMKLR1. The interaction of CMKLR1 with Chemerin induces pDC activation ａnd chemotaxis. It has been shown that CMKLR1 is a coreceptor for several strains of SIV ａnd HIV-1. CMKLR1 is a potential useful marker for distinguishing pDCs ａnd mDCs.Subcellular Location : Cell membrane; Multi-pass membrane protein.Tissue Specificity : Prominently expressed in developing osseous ａnd cartilaginous tissue. Also found in adult parathyroid glands. Prominently expressed in developing osseous ａnd cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues ａnd myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic ａnd immune function including, spleen, thymus, appendix, lymph node, bone marrow ａnd fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage ａnd immature dendritic cells （DCs）. High expression in blood monocytes ａnd low levels in polymorphonuclear cells ａnd T cells. Expressed on endothelial cells.Similarity : Belongs to the G-protein coupled receptor 1 family.