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CT-1/CTF1心肌营养素1抗体
点击次数：251发布时间：2012/12/3 21:02:43
更新日期：2024/9/5 14:42:48
所 在 地：中国大陆
产品型号：BY-2534R
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详细内容
货号：BY-2534R
英文名称：Anti-CT-1/CTF1
中文名称：心肌营养素1抗体
其他名称：cardiotrophin-1; Cardiophin1; Cardiotrophin 1; Cardiotrophin I; CardiotrophinI; CT1; CTF 1; CTF1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 22kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Cardiotrophin-1 （CT-1）, a cardiac hypertrophic factor, is a 21.5 kDa protein member of the IL-6 cytokine family. CT-1 is associated with the pathophysiology of heart diseases, including hypertension, myocardial infarction, valvular heart disease, ａnd congestive heart failure. The protein exerts its cellular effects by interacting with the glycoprotein 130 （gp130）/leukemia inhibitory factor receptor beta （LIFR） heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase （PI-3 kinase） in cardiac myocytes ａnd enhances transcription factor NF kappa B DNA -binding activities. CT-1 is highly expressed in the heart, skeletal muscle, prostate ａnd ovary ａnd to lower levels in lung, kidney, pancreas, thymus, testis ａnd small intestine.Function : Induces cardiac myocyte hypertrophy in vitro. Binds to ａnd activates the ILST/gp130 receptor.Subcellular Location : Secreted.Tissue Specificity : Highly expressed in heart, skeletal muscle, prostate ａnd ovary. Lower levels in lung, kidney, pancreas, thymus, testis ａnd small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.Similarity : Belongs to the IL-6 superfamily.
