本公司经销CD36L1/SRB1/HDL-R，高密度脂蛋白受体/清道夫受体抗体，克隆类型为polyclonal，宿主来源是Rabbit，CD36L1/SRB1/HDL-R高密度脂蛋白受体/清道夫受体抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1186R
英文名称：Anti-CD36L1/SRB1/HDL-R
中文名称：高密度脂蛋白受体/清道夫受体抗体
其他名称：High Density Lipoprotein Receptor; CD36 Antigen like 1; CD36L1; CLA 1; CLA1;SR BI; SRB1; SRBI; Scavenger Receptor BI; CD36 AND LIMPII ANALOGOUS 1; CD36 Antigen like 1; CD36L1; CLA 1; CLA1; Collagen type I receptor; MGC138242; SCARB1; Scavebger Receptor Class B Member 1; Scavenger Receptor Class B Type 1; SR BI; SRB1; SRBI; Thrombospondin receptor like 1; High density lipoprotein receptor SR-BI.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 61kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, chk, Rb, cow, hrs
产品介绍：High density lipoproteins （HDLs） play a critical role in cholesterol metabolism ａnd their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI （Scavenger Receptor BI） protein binds HDLs ａnd mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver ａnd nonplacental steroidgenic tissues, ａnd mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol ａnd the accumulation of cholesterol stores in the adrenal gland. Scavenging Receptor SR-BI plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer.Function : Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine ａnd apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free ａnd esterified cholesterol between the cell surface ａnd extracellular donors ａnd acceptors, such as HDL ａnd to a lesser extent, apoB-containing lipoproteins ａnd modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 ａnd E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester.Subunit : Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. The C-terminal region binds to PDZK1.Subcellular Location : Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol ａnd sphingomyelin-enriched domains within the plasma membrane, called caveolae.Tissue Specificity : Widely expressed.Post-translational modifications : N-glycosylated.The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.Similarity : Belongs to the CD36 family.组织细胞中存在多种高密度脂蛋白受体或高密度脂蛋白结合蛋白，这些受体蛋白的组成、结构及一般特征各不相同；高密度脂蛋白受体在脂质代谢中发挥着重要的作用。产品图片Overlay histogram showing Mouse SP2/0 stained with bs-1186R-FITC （red line）. The cells were fixed with 1% paraformaldehyde （10 min）. The cells were then incubated with the antibody （bs-1186R-FITC, 2ug/1x106cells） for 30 min at 22-25°C. Isotype control antibody （black line） was rabbit IgG （2ug/1x106cells） used under the same conditions. Acquisition of events were used for analysis.