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CIP2A/p90 Autoantigen蛋白磷酸酶PP2A癌抑制蛋白抗体
点击次数：195发布时间：2012/12/3 21:19:20
更新日期：2024/9/5 14:42:48
所 在 地：中国大陆
产品型号：BY-5948R
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详细内容
货号：BY-5948R
英文名称：Anti-CIP2A/p90 Autoantigen
中文名称：蛋白磷酸酶PP2A癌抑制蛋白抗体
其他名称：p90 Autoantigen Cancerous Inhibitor of Protein Phosphatase 2A; CIP2A; FLJ12850; KIAA1524; MGC163436; p90.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 100kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, hrs, dog, cow
产品介绍：Inhibition of protein phosphatase 2A （PP2A） activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A （CIP2A, p90 Autoantigen）, interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 （S62）, ａnd thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, p90 Autoantigen promotes anchorage-independent cell growth ａnd in vivo tumor formation. The oncogenic activity of p90 Autoantigen is demonstrated by transformation of human cells by overexpression of p90 Autoantigen. Importantly, p90 Autoantigen is overexpressed in two common human malignancies, head ａnd neck squamous cell carcinoma （HNSCC） ａnd colon cancer.Subunit : Interacts with MYC.Subcellular Location : Membrane; Single-pass membrane protein （Potential）. Cytoplasm. Note=Slightly concentrates in the perinuclear region.Tissue Specificity : Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas （HNSCC）. Present in liver cancer cells （at protein level）.
