产品展示
Cripto-1/CRIPT畸胎瘤衍化生长因子抗体(C端)
点击次数：211发布时间：2012/12/3 21:21:38
更新日期：2024/9/5 14:42:48
所 在 地：中国大陆
产品型号：BY-2141R
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详细内容
货号：BY-2141R
英文名称：Anti-Cripto-1/CRIPT
中文名称：畸胎瘤衍化生长因子抗体（C端）
其他名称：CR; CRGF; Cripto 1; Cripto 1 growth factor; Cripto1; Cripto1 growth factor; Epidermal growth factor like cripto protein CR1; TDGF 1; TDGF1; Teratocarcinoma derived growth factor 1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 21kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：The cripto gene is expressed both in ES cells ａnd during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers. It could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.Function : Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.Subcellular Location : Cell membrane.Tissue Specificity : Preferentially expressed in gastric ａnd colorectal carcinomas than in their normal counterparts.Similarity : Contains 1 EGF-like domain.Cripto-1（表皮生长因子相关肽）是Cripto-FRL-Criptic（EGF-CFC）家族成员, 属于转化生长细胞TGF-β蛋白家族及Nodal蛋白质的共同受体。Cripto蛋白对于胚胎的发育占有非常重要的地位。 Cripto-1在人类的多种肿瘤如结肠癌、乳腺癌、卵巢癌、胰腺癌等中高表达，可激活P13K/Akt/GSK-3βc-Src和ras/raf/MAPK信号通路,介导细胞增殖和抑制细胞凋亡，Cripto蛋白的单细胞繁殖抗体，可以有效抑制一些癌细胞的生长。
