本公司经销CD133，造血干细胞抗原CD133抗体，克隆类型为polyclonal，宿主来源是Rabbit，CD133造血干细胞抗原CD133抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-4770R
英文名称：Anti-CD133
中文名称：造血干细胞抗原CD133抗体
其他名称：AC133; Antigen AC133; Hematopoietic stem cell antigen; hProminin; PROM1; Prominin I; Prominin like protein 1 precursor; Prominin mouse like 1; prominin1; PROML1; CD133; CORD12; MCDR2; MSTP061; PROML1; RP41; STGD4.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 95kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Prominin is a novel plasma membrane protein with an N-terminal extracellular domain, five transmembrane segments flanking two short cytoplasmic loops ａnd two large glycosylated extracellular domains, ａnd a cytoplasmic C-terminal domain. DNA sequences from Caenorhabditis elegans predict the existence of a protein with the same features, suggesting that prominin is conserved between vertebrates ａnd invertebrates. Prominin is found not only in the neuroepithelium but also in various other epithelia of the mouse embryo. In the adult mouse, prominin has been detected in the brain ependymal layer, ａnd in kidney tubules. In these epithelia, prominin is specific to the apical surface, where it is selectively associated with microvilli ａnd microvilli-related structures. Remarkably, upon expression in CHO cells, prominin is preferentially localized to plasma membrane protrusions such as filopodia, lamellipodia, ａnd microspikes. These observations imply that prominin contains information to be targeted to, and/or retained in, plasma membrane protrusions rather than the planar cell surface. Moreover, results show that the mechanisms underlying targeting of membrane proteins to microvilli of epithelial cells ａnd to plasma membrane protrusions of non-epithelial cells are highly related.Subunit : Interacts with CDHR1 ａnd with actin filaments.Subcellular Location : Cell projection, cilium, photoreceptor outer segment. Isoform 1: Apical cell membrane; Multi-pass membrane protein. Cell projection, microvillus membrane; Multi-pass membrane protein.Similarity : Belongs to the prominin family.一般认为，VEGFR2（血管内皮生长因子受体2）是HSCs（造血干细胞）的特异性的表面标志。近来经研究发现CD133分子是HSCs（造血干细胞）特异性标志。CD133即AC133，是一个新发现的HSCs（造血干细胞）表面标志，在HSCs（造血干细胞）分化成熟过程中，CD133的含量迅速降低。EPCs（血管内皮前体细胞）区别于成熟内皮细胞的主要标志是CD133。经研究发现内皮细胞不能结合CD133的抗体。证实分化成熟的内皮细胞不具有CD133。这些说明CD133可以作为EPCs（血管内皮前体细胞）区别于成熟内皮细胞的一个表面标志.