本公司经销Cathepsin K，组织蛋白酶K抗体，克隆类型为polyclonal，宿主来源是Rabbit，Cathepsin K组织蛋白酶K抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1611R
英文名称：Anti-Cathepsin K
中文名称：组织蛋白酶K抗体
其他名称：Cathepsin K; Procathepsin K; Cathepsin K precursor; Cathepsin O; Cathepsin O1; Cathepsin O2; Cathepsin X; CathepsinK; CTS02; CTSK; CTSK protein; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD; Pycnodysostosis; cath-K; CK.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 36kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, dog, pig, Gpig, hrs
产品介绍：Cathepsin family of proteases contains several diverse classes of enzymes. The cysteine protease class comprises cathepsin B, H, K, L, O, ａnd S. The aspartyl protease class contains cathepsin D ａnd E. Cathepsin G belongs to the serine protease class. Cathepsins are involved in various cellular events such as peptide biosynthesis, protein degradation, ａnd apoptosis. Cathepsin K expression is highest in bone, cartilage, ａnd skeletal muscle. Cathepson K is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in the gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis ａnd short stature.Function : Closely involved in osteoclastic bone resorption ａnd may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.Subunit : Belongs to the peptidase C1 family.Subcellular Location : Lysosome.Tissue Specificity : Tissue specificityPredominantly expressed in osteclasts （bones）.DISEASE : Defects in CTSK are the cause of pycnodysostosis （PKND） [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis ａnd short stature.合成与降解（Synthesis ａnd Degradation）组织蛋白酶K（cathepsinK）是半胱氨酸蛋白酶家族的成员,它和组织蛋白酶S、L和B有很高的同源性。在心血管方面：组织蛋白酶K参与心血管的很多病理生理过程，在动脉硬化、血管重塑与再生。也是动脉瘤生长、破裂、主动脉辩狭窄进程中主要的胶原酶。在骨与关节方面：组织蛋白酶K主要位于破骨细胞，是涉及骨质再吸收的主要酶，与骨质疏松与脱钙密切相关。产品图片Antigen: bs-1611P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.