本公司经销Cathepsin D/CTSD，组织蛋白酶D抗体，克隆类型为polyclonal，宿主来源是Rabbit，Cathepsin D/CTSD组织蛋白酶D抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1615R
英文名称：Anti-Cathepsin D/CTSD
中文名称：组织蛋白酶D抗体
其他名称：CatD; CathepsinD; CLN10; CPSD; CTSD; Lysosomal aspartyl peptidase; MGC2311
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 42kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, dog, cow, Rb
产品介绍：Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, ａnd contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment ａnd an internal cleavage to generate the two-chain form made up of 34 ａnd 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed ａnd is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation ａnd may be a useful prognostic indicator for breast cancer ａnd possibly Alzheimer＇s disease.Function : Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer ａnd possibly Alzheimer disease.Subunit : Belongs to the peptidase A1 family.Subcellular Location : Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.DISEASE : Defects in CTSD are the cause of neuronal ceroid lipofuscinosis type 10 （CLN10）; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, ａnd clinically by seizures, dementia, visual loss, and/or cerebral atrophy.