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Phospho-Beta-Catenin (Ser675)磷酸化β 连环素蛋白抗体
点击次数：162发布时间：2012/12/3 21:29:25
更新日期：2024/9/5 14:42:48
所 在 地：中国大陆
产品型号：BY-3087R
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货号：BY-3087R
英文名称：Anti-Phospho-Beta-Catenin （Ser675）
中文名称：磷酸化β 连环素蛋白抗体
其他名称：CTNNB1; CHBCAT; CTNNB1; CTNNB; Beta-catenin; Catenin beta-1; PRO2286; FLJ37923; FLJ25606; DKFZp686D02253.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 92kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, hrs, cow, shp, chk, Rb
产品介绍：This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia ａnd mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth ａnd differentiation during both normal development ａnd tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Subcellular Location : "Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction. Cell membrane. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole.Tissue Specificity : Expressed in several hair follicle cell types: basal ａnd peripheral matrix cells, ａnd cells of the outer ａnd inner root sheaths. Expressed in colon.Similarity : Belongs to the beta-catenin family.Contains 12 ARM repeats.细胞粘附蛋白（Call Adhesion Protein） β连环素蛋白β-catenin是一种多功能的蛋白质，能链接E-\\N-,钙粘附分子具有参与细胞粘附和介导信号转导的双重功能，并与肿瘤的发生发展及浸润密切相关。 在正常个体中，β-catenin和钙黏蛋白形成复合体，介导同型细胞的粘附，维持细胞的稳定；同时，β-catenin作为Wnt/β-catenin信号通路的关键成员在介导信号转导过程中调控细胞的增殖和凋亡。 在恶性肿瘤中，β-catenin的表达呈现明显的异质性，促使细胞异常增殖，还可使细胞之间的黏附性减弱，侵袭性增强。
