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CNTN5/Contactin 5轴突蛋白5抗体
点击次数：463发布时间：2012/12/3 21:34:33
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-11453R
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货号：BY-11453R
英文名称：Anti-CNTN5/Contactin 5
中文名称：轴突蛋白5抗体
其他名称：Contactin5;Contactin-5;hNB 2;HNB 2s;NB 2;Neural recognition molecule NB 2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 121kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Changes in synaptic efficacy can mediate crucial processes during learning ａnd memory formation. Accumulating evidence implicates cell adhesion molecules in activity-dependent synaptic modifications associated with paired-pulse facilitation （PPF）, long-term potentiation （LTP） ａnd long-term depression （LTD）. Among the cell adhesion molecules involved in these processes are the contactins. Contactins are immunoglobulin superfamily members that play a selective role in synaptic plasticity, PPF ａnd LTD, ａnd may regulate cell-cell interactions contributing to synaptic plasticity in conjunction with other synapse targeting molecules, including paranodin ａnd phosphacan. In addition, contactins are essential components that control expression ａnd distribution of Na+ channels in neurons, junctional attachment at the paranode, ａnd ultimately the physiology of the myelinated nerve. The human Contactin 1 gene encodes a 1,018 amino acid protein. The human Contactin 3 gene encodes a 646 amino acid plasmacytoma-associated neuronal glycoprotein. The human Contactin 5 gene encodes a 1,100 amino acid neural adhesion molecule. The human Contactin 6 gene encodes a 1,028 amino acid neural adhesion molecule.Function : CNTN5 is a member of the immunoglobulin superfamily. Contactins mediate cell surface interactions during the development of the nervous system. CNTN5 has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons ａnd is most likely involved in neuronal activity in the auditory system. Subcellular Location : Cell membrane; Lipid-anchor, GPI-anchor.
