本公司经销CRY2/Cryptochrome 2，隐花色素蛋白2抗体，克隆类型为polyclonal，宿主来源是Rabbit，CRY2/Cryptochrome 2隐花色素蛋白2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11447R
英文名称：Anti-CRY2/Cryptochrome 2
中文名称：隐花色素蛋白2抗体
其他名称：cry2; CRY2_HUMAN; cryptochrome 2 （photolyase like）; Cryptochrome2; Cryptochrome-2; FLJ10332; growth inhibiting protein 37; HCRY2; KIAA0658; PHLL2; Photolyase like.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 65kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mop, rat, pig, chk, cow, dog, hrs, shp
产品介绍：Circadian clocks are biological timepieces that regulate hormonal rhythms, sleep cycles ａnd feeding behaviors. These rhythms are generated in the superchiasmatic nucleus （SCN）, a cell-autonomous circadian oscillator located within the brain that is synchronized with the environment by light. A number of transcription factors, including Clock ａnd BMAL1, are molecular components of the SCN that induce the expression of proteins involved in light/dark cycle entrainment, which include Per1 ａnd Per2. Tim, for timeless, generates a negative feedback loop that regulates the activity of Clock by suppressing the expression of Clock target genes. Tim forms heterodimers with Per1 ａnd Per2 that bind Clock ａnd block the activation of Clock-BMAL1 dimers to repress Per gene expression. Additionally, the CRY proteins, which are cryptochrome photoreceptors for the circadian clock, function as light-independent inhibitors of the circadian clock. CRY1 ａnd CRY2 negatively regulate SCN components by associating with the activators Clock-BMAL1, ａnd also with the various feedback inhibitors Per1, Per2 ａnd Tim.Function : Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCKNPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length ａnd circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCKNPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.Subunit : Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS, ａnd the PER proteins. Interacts directly with PER1 ａnd PER2 C-terminal domains. Interaction with PER2 inhibits its ubiquitination ａnd vice versa. Interacts with NFIL3. Interacts with FBXL3.Subcellular Location : Cytoplasm. Nucleus. Translocated to the nucleus through interaction with other Clock proteins such as PER2 or ARNTL.Tissue Specificity : Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon ａnd leukocytes. Highest levels in heart ａnd skeletal muscle.Post-translational modifications : Phosphorylation on Ser-266 by MAPK is important for the inhibition of CLOCK-ARNTL-mediated transcriptional activity. Phosphorylation by CSKNE requires interaction with PER1 or PER2.Ubiquitinated by the SCF（FBXL3） ａnd SCF（FBXL21） complex, leading to its degradation.Similarity : Belongs to the DNA photolyase class-1 family.Contains 1 DNA photolyase domain.