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货号：BY-11169R
英文名称：Anti-Cadherin 10
中文名称：钙粘附分子10抗体
其他名称：cadherin10;cadherin-10;Cadherin 10 （T2 cadherin）;Cadherin 10 type 2 （T2 cadherin）;Cadherin 10 type 2;Cadherin10;T2 cadherin.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 88kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of structure ａnd morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. T2-cadherin, also known as cadherin-10 or CDH10, is a 788 amino acid single-pass type I membrane protein that belongs to the cadherin family ａnd contains five cadherin domains. Expressed predominately in brain, but also found in prostate ａnd both adult ａnd fetal kidney, T2-cadherin functions as a calcium-dependent cell adhesion protein that is thought to be involved in the maintenance of synaptic adhesions, axon outgrowth ａnd guidance.Function : Cadherin 10 is a type II classical cadherin from the cadherin superfamily. These are integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, ａnd a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, ａnd appears to determine the specificity of the protein＇s homophilic cell adhesion activity. Type II （atypical） cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain ａnd is putatively involved in synaptic adhesions, axon outgrowth ａnd guidance. Subcellular Location : Cell membrane; Single-pass type I membrane protein
