本公司经销CD172a/SIRP Alpha，信号调节蛋白α抗体，克隆类型为polyclonal，宿主来源是Rabbit，CD172a/SIRP Alpha信号调节蛋白α抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2708R
英文名称：Anti-CD172a/SIRP Alpha
中文名称：信号调节蛋白α抗体
其他名称：Signal regulatory protein alpha type 1; BIT; Brain Ig like molecule with tyrosine based activation motifs; Brain immunoglobulin like molecule with tyrosine based activation motifs; CD172 antigen like family member A; CD172a; CD172a antigen; Inhibitory receptor SHPS1; Macrophage fusion receptor; MFR; MYD 1; Myd 1; MYD1; p84;Protein tyrosine phosphatase non receptor type substrate 1; PTPNS1; SHP Substrate 1; SHPS1; Signal regulatory protein alpha 2; Signal regulatory protein alpha 3; Signal regulatory protein alpha; Signal Regulatory Protein Alpha Type 1; Signal regulatory protein alpha type 2; SIRP; SIRPA; SIRPalpha; SIRPalpha1; SIRPalpha2; SIRPalpha3; Tyrosine phosphatase SHP substrate 1; Tyrosine protein phosphatase non receptor type substrate 1; Tyrosine protein phosphatase non receptor type substrate.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 56kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow, hrs, pig, hrs
产品介绍：Protein tyrosine phosphatases （PTPases） SHP1 ａnd SHP2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP2 is a signal transducer for several receptor tyrosine kinases ａnd cytokine receptors. A novel SHP2 associated glycoprotein was recently cloned from human, rat, mouse ａnd cattle by several labs ａnd was designated SIRPa （1）,SHPS1 , MyD1, BIT ａnd p84. SIRPa is a new gene family containing at least fifteen members. SIRPa is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR ａnd src, ａnd a specific docking protein for SHP2. SIRPa has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones ａnd cell adhesion ａnd plays a general role in different physiological ａnd pathological processes.Subunit : Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR （By similarity）. Binds JAK2 irrespective of its phosphorylation status ａnd forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B.Subcellular Location : Membrane; Single-pass type I membraneprotein.Tissue Specificity : Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle ａnd pancreas.Similarity : Contains 2 Ig-like C1-type （immunoglobulin-like） domains. Contains 1 Ig-like V-type （immunoglobulin-like） domain.