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CD150/SLAMF1信号淋巴细胞活化分子CD150抗体
点击次数:232发布时间:2012/12/3 21:42:59
更新日期:2024/9/5 14:43:01
所 在 地:中国大陆
产品型号:BY-2709R
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货号:BY-2709R
英文名称:Anti-CD150/SLAMF1
中文名称:信号淋巴细胞活化分子CD150抗体
其他名称:CD150 antigen; Cdw150; Estm51; Ipo 3; Ipo3; MGC151472; MGC151476; Signaling lymphocytic activation molecule; Signaling lymphocytic activation molecule family member 1; Signaling lymphocytic activation molecule precursor; Slaf1; SLAM family, member 1; Slamf; Slamf1; SLAMF1 protein.
抗体来源:Rabbit
克隆类型:polyclonal
蛋白分子量:predicted molecular weight: 70kDa
纯化方法:affinity purified by Protein A
交叉反应:hu, rat, mo, dog, pig, cow, hrs, shp
产品介绍:SLAM, a novel glycoprotein of 37kDa, designated SLAM (Signaling Lymphocyte Activation Molecule) or CDw150, belongs to the immunoglobulin gene superfamily and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound form of SLAM and the soluble and cytoplasmic isoforms of SLAM, and the expression levels of membrane bound SLAM on B cells are rapidly regulated after activation in vitro. It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells. Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells.CD150(SLAM)为70kD的表面糖蛋白属于免疫球蛋白基因超家族。SLAM有直接诱导CD4阳性T细胞克隆与活化前T细胞的作用。CD150抗原还可以增强抗原特异性增生与通过T细胞携带的CD4抗原产生细胞因子,特别是对干扰素-γ具有极强的上调节作用。SLAM与自身配体具有极高亲和性,由SLAM同源亲和细胞间的相互作用能够刺激T淋巴细胞产生自身因子。CD150抗原还是风疹病毒细胞受体并且通过白介素10下调节。