本公司经销CDCA5/Sororin，细胞分裂周期相关蛋白5抗体，克隆类型为polyclonal，宿主来源是Rabbit，CDCA5/Sororin细胞分裂周期相关蛋白5抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-7717R
英文名称：Anti-CDCA5/Sororin
中文名称：细胞分裂周期相关蛋白5抗体
其他名称：Cell division cycle associated protein 5; MGC16386; p35; Sororin.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 28kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, dog, pig, cow, Rb
产品介绍：Sororin, also designated cell division cycle-associated protein 5 （CDCA5） or p35, functions as a regulator of sister chromatid cohesion during mitosis. It interacts with the APC/C complex ａnd is found in a complex consisting of cohesion components SCC-112, MC1L1, SMC3L1, RAD21 ａnd APRIN. The deduced human ａnd mouse Sororin proteins consist of 252 ａnd 264 amino acid residues, respectively, ａnd both contain a KEN box for APC-dependent ubiquitination. Reserach demonstrates a punctated nuclear distribution of Sororin during interphase ａnd a diffuse distribution throughout the cell during mitosis. There is no apparent concentration of Sororin on chromatin in mitotic cells ａnd Sororin levels decrease in synchronized HeLa cells during interphase. The Sororin gene maps to chromosome 11q12.1.Function : CDCA5 is a regulator of sister chromatid cohesion in mitosis. It may act by regulating the ability of the cohesin complex to mediate sister chromatid cohesion, perhaps by altering the nature of the interaction of cohesin with the chromosomes. CDCA5 interacts with the APC/C complex ａnd is found in a complex with the cohesin components SMC1L1, SMC3L1, RAD21, PDS5A/APRIN ａnd PDS5B/SCC-112.Subunit : Interacts with the APC/C complex （By similarity）. Interacts with the chromatin-bound cohesin complex; the interaction is indirect, occurs after DNA replication ａnd requires acetylation of the cohesin component SMC3. Interacts （via the FGF motif） with PDS5A ａnd PDS5B; the interaction is direct ａnd prevents the interaction of PDS5A with WAPAL.Subcellular Location : Nuclear.Post-translational modifications : Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A ａnd relieves the inhibition of WAPAL by CDCA5.Ubiquitinated by the APC/C complex in G1, leading to its degradation （Probable）.Similarity : Belongs to the sororin family.