本公司经销CDC10/Septin 7，细胞周期调控因子3抗体，克隆类型为polyclonal，宿主来源是Rabbit，CDC10/Septin 7细胞周期调控因子3抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-7741R
英文名称：Anti-CDC10/Septin 7
中文名称：细胞周期调控因子3抗体
其他名称：Cdc3p; Cell division control protein 3; SEPT7A; CDC10; CDC10 protein homolog; CDC3; Cell division cycle 10; Septin7; Septin-7; Septin 7; SEPT7_HUMAN.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 50kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, zebrafish
产品介绍：This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila ａnd with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane ａnd is essential for cytokinesis. This human protein functions in gliomagenesis ａnd in the suppression of glioma cell growth, ａnd it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 ａnd 19. [provided by RefSeq, Jul 2011].Function : Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis ａnd collective cell movements.Subunit : Septins polymerize into heterooligomeric protein complexes that form filaments, ａnd associate with cellular membranes, actin filaments ａnd microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 ａnd SEPT7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPT6, while interaction with SEPT2 seems indirect. In the absence of SEPT6, forms homodimers. Interacts directly with CENPE ａnd links CENPE to septin filaments composed of SEPT2, SEPT6 ａnd SEPT7. Interacts with SEPT5 ａnd SEPT8. Interacts with SEPT9 ａnd SEPT11.Subcellular Location : Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Cytoplasm, cytoskeleton, cilium axoneme. Note=Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle ａnd at the cleavage furrow in anaphase cells. Detected at the midbody in telophase. Associated with actin stress fibers.Tissue Specificity : Widely expressed.Similarity : Belongs to the septin family.