产品展示
CR1/CD35Ⅰ型补体受体抗体（C3b/C4b受体抗体）
点击次数：290发布时间：2012/12/3 21:51:24
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-2596R
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详细内容
货号：BY-2596R
英文名称：Anti-CR1/CD35
中文名称：Ⅰ型补体受体抗体（C3b/C4b受体抗体）
其他名称：Complement receptor type 1; CR1; C3BR; C4BR; CD35; KN; C3-binding protein; CD35 antigen; complement component receptor 1; C3b/C4b receptor; Knops blood group antigen.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 274kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：This gene is a member of the receptors of complement activation （RCA） family ａnd is located in the ＇cluster RCA＇ region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, ａnd splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles ａnd immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus ａnd sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.Subunit : Monomer.Subcellular Location : Membrane; Single-pass type I membrane protein.Tissue Specificity : Present on erythrocytes, leukocytes, glomerular podocytes, ａnd splenic follicular dendritic cells.Similarity : Belongs to the receptors of complement activation （RCA） family.Contains 30 Sushi （CCP/SCR） domains. CD35广泛分布于红细胞、粒细胞、单核细胞、肥大细胞、滤泡树突状细胞、肾小球足突细胞、B细胞及部分CD4+T细胞表面.CD35抗原又称为CR1或者C3b/C4b R，是一种分子量160-250kDa的C3b/C4b补体结合跨膜蛋白，主要用于滤泡树突状细胞标记和滤泡树突状细胞瘤的诊断。
