本公司经销CACNB2，L-型电压依赖型钙通道β抗体，克隆类型为polyclonal，宿主来源是Rabbit，CACNB2L-型电压依赖型钙通道β抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2996R
英文名称：Anti-CACNB2
中文名称：L-型电压依赖型钙通道β抗体
其他名称：Voltage-dependent L-type calcium channel subunit beta-2; CAB2; Cacnb2; Cacnlb2; VDCC-L Beta; Calcium channel voltage-dependent subunit beta 2; calcium channel, voltage-dependent, beta 2 subunit; calcium channel beta 2c subunit; calcium channel L-type beta 2 subunit.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 72kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, Rb, dog, chk
产品介绍：CACNB2 is a subunit of a voltage-dependent calcium channel protein which is a member of the voltage-gated calcium channel superfamily, expressed in the CNS. The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation ａnd inactivation, modulating G protein inhibition ａnd controlling the alpha-1 subunit membrane targeting. It was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome which is an autoimmune disorder. Mutations in this gene are associated with Brugada symdrome. Alternatively spliced variants have been identified for this gene.Function : The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation ａnd inactivation, modulating G protein inhibition ａnd controlling the alpha-1 subunit membrane targeting.Subunit : The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta ａnd gamma. Interacts with RRAD. Interaction with RRAD regulates the trafficking of CACNA1C to the cell membrane.Subcellular Location : Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.Similarity : Belongs to the calcium channel beta subunit family.Contains 1 SH3 domain.电压依赖性钙通道（VDCC）是生物体内一大类钙通道蛋白,随着膜电位的改变而出现通道的开放、关闭和失活,调节细胞内Ca2+浓度,*终产生生物学效应.其亚型结构各异,VDCC β亚基具有调节其通道活性的作用,VDCC存在的普遍性决定了其作用的广泛性.在胰腺、心、脑、肾上腺、视网膜及神经等组织器官均有不同程度的分布.