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Phospho-cdc2 (Ser39)磷酸化周期素依赖激酶2抗体
点击次数：496发布时间：2012/12/3 21:58:34
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-5247R
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货号：BY-5247R
英文名称：Anti-Phospho-cdc2 （Ser39）
中文名称：磷酸化周期素依赖激酶2抗体
其他名称：P34CDC2; Cdc 2; CDK 1; CDK1; Cell division control protein 2; Cell division control protein 2 homolog; Cell division cycle 2 G1 to S ａnd G2 to M; Cell Divsion Cycle 2 Protein.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 34kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：The cell division control protein cdc2, also known as cyclin dependent kinase 1 （Cdk1） or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S phase ａnd mitosis. Cdc2 exists as a complex with both cyclin A ａnd cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding ａnd phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 ａnd Tyr14. Phosphorylation at Tyr15 ａnd inhibition of Cdc2 is carried out by WEE1 ａnd MIK protein kinases while Tyr15 dephosphorylation ａnd activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development ａnd degeneration.Cdc2蛋白激酶也被称作细胞周期蛋白依赖性激酶1 （cyclin-dependent kinase 1, CDK1）或M期促进因子（M-phase promoting factor, MPF），是细胞周期蛋白依赖性激酶家族成员，参与真核细胞周期的调控。Cdc2-cyclin B活化后可启动有丝分裂，其活化受到严格调控。Cdc2-cyclin B是丝氨酸/苏氨酸蛋白酶，由催化亚基Cdc2和正向调节亚基cyclin B （B1 异构体） 组成。Cdc2与细胞周期蛋白B的结合对激酶的激活是非常重要的。在G2期，Cdc2-cyclin B处于非活化状态，这是因为其两个负向调控位点T14和T15分别被抑制蛋白激酶Myt1和Wee1磷酸化。在G2后期，T14和T15两个位点在Cdc25C蛋白磷酸酶作用下去磷酸化，使Cdc2-cyclin B复合体活化，从而引发有丝分裂的启始。
