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Ceruloplasmin铜蓝蛋白抗体
点击次数：362发布时间：2012/12/3 22:01:22
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-2373R
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详细内容
货号：BY-2373R
英文名称：Anti-Ceruloplasmin
中文名称：铜蓝蛋白抗体
其他名称：CER; caeruloplasmin; Ceruloplasmin precursor; CP 2; CP; CP2; CP-2; EC 1.16.3.1; Ferroxidase.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 120kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, dog, Rb
产品介绍：Caeruloplasmin is a copper binding plasma glycoprotein consisting of a single polypeptide chain. It has a molecular weight of 132kDa ａnd occurs in plasma at a concentration of 150-500 mg/L. Although the physiological functions of Caeruloplasmin are not fully understood it is implicated in a number of possible functions. 95% of plasma copper is bound to Caeruloplasmin, implying some involvement in copper transport. Caeruloplasmin has been described as both an oxidant ａnd an antioxidant, its exact role or roles in this respect are not clear. Plasma levels of Caeruloplasmin are elevated after inflammation ａnd trauma ａnd it is therefore classified as an acute phase protein. The measurement of Caeruloplasmin in plasma is useful in the diagnosis of Wilson’s disease, where levels are greatly reduced. Caeruloplasmin is extremely labile in plasma ａnd rapidly degrades to 115kDa ａnd 19kDa fragments. The age of plasma samples should therefore be taken into account when interpreting immunological analysis of caeruloplasmin.铜蓝蛋白（ceruloplasmin,CER）又称铜氧化酶，是一种含铜的α2糖蛋白，CER具有氧化酶的活性，起着抗氧化剂的作用。在血循环中CER的抗氧化活力可以防止组织中脂质过氧化物和自由基的生成，特别在炎症时具有重要意义,也属于一种急性时相反应蛋白。铜蓝蛋白对多酚及多胺类底物有催化其氧化之能力铜蓝蛋白具有遗传上的基因多形性。其作用为调节铜在机体各个部位的分布、合成含铜的酶蛋白.一般认为铜蓝蛋白由肝脏合成，一部分由胆道排泄，尿中含量甚微。铜蓝蛋白测定对某些肝、胆、肾等疾病的诊断有一定意义。产品图片Antigen: bs-2373P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.
