本公司经销Collagen II/Chondrocalcin，Ⅱ型胶原α1蛋白/软骨钙素抗体，克隆类型为polyclonal，宿主来源是Rabbit，Collagen II/ChondrocalcinⅡ型胶原α1蛋白/软骨钙素抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-4851R
英文名称：Anti-Collagen II/Chondrocalcin
中文名称：Ⅱ型胶原α1蛋白/软骨钙素抗体
其他名称：Collagen II alpha 1; COL2A1; COL2A1 protein; collagen, type II, alpha 1; collagen alpha-1（II）; type II collagen; alpha-1 type II collagen; alpha1 type II collagen; Col2a1; AOM; Cartilage collagen; Chondrocalcin; COL11A3; Collagen alpha 1（II） chain precursor; Collagen II alpha 1 polypeptide; Collagen type II alpha 1 （primary osteoarthritis spondyloepiphyseal dysplasia congenital）; MGC131516; SEDC.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 117kDa
纯化方法：affinity purified by Protein A
交叉反应：pig, hrs, cow, dog, Rb, hu, mo, rat
产品介绍：The extensive family of COL gene products （collagens） is composed of several chain types, including fibril-forming interstitial collagens （types I, II, III ａnd V） ａnd basement membrane collagens （type IV）, each type containing multiple isoforms. Collagens are fibrous, extracellular matrix proteins with high tensile strength ａnd are the major components of connective tissue, such as tendons ａnd cartilage. All collagens contain a triple helix domain ａnd frequently show lateral self-association in order to form complex connective tissues. Several collagens also play a role in cell adhesion, important for maintaining normal tissue architecture ａnd function. In cartilage, Collagen Type II constitutes the bulk of the fibril. Sensitization with Collagen Type II induces an erosive polyarthritis in rats, mice ａnd higher primates which can resemble rheumatoid arthritis ａnd relapsing polychrondritis.Function : Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth ａnd for the ability of cartilage to resist compressive forces.Subcellular Location : Secreted > extracellular space > extracellular matrix.Tissue Specificity : Isoform 2 is highly expressed in juvenile chondrocyte ａnd low in fetal chondrocyte.DISEASE : Defects in COL2A1 are the cause of spondyloepiphyseal dysplasia congenital type （SEDC）. This disorder is characterized by disproportionate short stature ａnd pleiotropic involvement of the skeletal ａnd ocular systems.Defects in COL2A1 are the cause of spondyloepimetaphyseal dysplasia Strudwick type （SEMD-STR）. A bone disease characterized by disproportionate short stature from birth, with a very short trunk ａnd shortened limbs, ａnd skeletal abnormalities including lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, ａnd abnormal epiphyses or metaphyses. A distinctive radiographic feature is irregular sclerotic changes, described as dappled in the metaphyses of the long bones.