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phospho-CD244(Tyr271)磷酸化CD244抗体
点击次数：272发布时间：2012/12/3 22:07:56
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-5284R
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详细内容
货号：BY-5284R
英文名称：Anti-phospho-CD244（Tyr271）
中文名称：磷酸化CD244抗体
其他名称：NKR2B4; SLAMF4; natural killer cell receptor 2B4 isoform 2 precursor; 2B4 ; C9.1; CD244 antigen; CD244 molecule natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; F730046O15Rik; h2B4; Ly90; NAIL; Natural killer cell activation-inducing ligand; Natural killer cell receptor 2B4; NK cell activation inducing ligand; NK cell activation inducing ligand NAIL; NK cell type I receptor protein 2B4; Nmrk; Non-MHC restricted killing associated; OTTHUMP00000027884; p38; SLAM family, member 4.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 38kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, hrs, pig, Rb
产品介绍：CD244 is expressed on all human NK cells, a subpopulation of T cells, basophils ａnd monocytes. CD244 activates NK cell mediated cytotoxicity, induces secretion of IFN-gamma ａnd matrix metalloproteinases, ａnd NK cell invasiveness. Although there have been several molecules shown to interact with CD244, the signaling mechanism ofCD244-mediated activation of NK cells is still unknown. It is a high affinity receptor for CD48.Function : Modulate other receptor-ligand interactions to enhance leukocyte activation.Subunit : Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 ａnd SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2.Subcellular Location : Membrane; Single-pass type I membrane protein （Potential）.Tissue Specificity : Expressed in spleen, PBL, followed by lung, liver, testis ａnd small intestine. Expressed not only in NK cells, but also on monocytes ａnd basophils.Similarity : Contains 2 Ig-like （immunoglobulin-like） domains.
