本公司经销phospho-CHEK1 （Ser280），磷酸化细胞周期检测点激酶1抗体，克隆类型为polyclonal，宿主来源是Rabbit，phospho-CHEK1 （Ser280）磷酸化细胞周期检测点激酶1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-5250R
英文名称：Anti-phospho-CHEK1 （Ser280）
中文名称：磷酸化细胞周期检测点激酶1抗体
其他名称：Chk1 （Phospho-Ser280）; Cell cycle checkpoint kinase; Checkpoint , S. pombe, homolog of, 1; Checkpoint kinase 1; Checkpoint kinase 1 homolog （S. pombe）; CHEK 1; CHEK1; Chk 1; Chk1; CHK1 checkpoint homolog （S. pombe）; EC 2.7.11.1; rad27; Serine/threonine protein kinase Chk1; STT3, subunit of the oligosaccharyltransferase complex, homolog A （S. cerevisiae）.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 52kDa
纯化方法：affinity purified by Protein A
交叉反应：mo, rat, Rb, hu
产品介绍：One mechanism by which checkpoints maintain the fidelity of cell cycle events is through blocking mitosis in response to unreplicated or damaged DNA. In most species this occurs through inhibiting activation of the cyclic dependent kinase Cdc2, which regulates entry into mitosis. Chk1, a kinase involved in the DNA damage checkpoint response can phosphorylate Cdc25C an activator of Cdc2. It is hypothesized that Chk1 induces serine 216 phosphorylation of Cdc25C ａnd subsequent 14-3-3 binding negatively regulated Cdc25C, thus preventing it from activating Cdc2.Subunit : Interacts （phosphorylated by ATR） with RAD51. Interacts with ａnd phosphorylates CLSPN, an adapter protein that regulates the ATR-dependent phosphorylation of CHEK1. Interacts with BRCA1. Interacts with ａnd phosphorylates CDC25A, CDC25B ａnd CDC25C. Interacts with FBXO6, which regulates CHEK1. Interacts with PPM1D, which regulates CHEK1 through dephosphorylation. Interacts with TIMELESS; DNA damage-dependent. Interacts with FEM1B; activates CHEK1 in response to stress. Interacts with TLK1. Interacts with XPO1 ａnd YWHAZ.Subcellular Location : Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Note=Nuclear export is mediated at least in part by XPO1/CRM1. Also localizes to the centrosome specifically during interphase, where it may protect centrosomal CDC2 kinase from inappropriate activation by cytoplasmic CDC25B.Tissue Specificity : Expressed ubiquitously with the most abundant expression in thymus, testis, small intestine ａnd colon.Similarity : Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. Contains 1 protein kinase domain.Chk1作为Cdks的调节参与细胞周期调节过程,是生物进化过程中非常保守的蛋白激酶，在DNA损伤引起的细胞周期检测点调节中有着非常重要的作用.在细胞周期检测点信号传导通路中，Chkl和Chk2起着重要作用，主要参与G2/M期细胞周期检测点信号传导.